TY - JOUR
AU - Li, Lijun
AU - Deng, Jikui
AU - Ma, Xiang
AU - Zhou, Kai
AU - Meng, Qinghong
AU - Yuan, Lin
AU - Shi, Wei
AU - Wang, Qing
AU - Li, Yue
AU - Yao, Kaihu
T1 - High Prevalence of Macrolide-Resistant Bordetella pertussis and ptxP1 Genotype, Mainland China, 2014–2016
T2 - Emerging Infectious Disease journal
PY - 2019
VL - 25
IS - 12
SP - 2205
SN - 1080-6059
AB - According to the government of China, reported cases of pertussis have increased remarkably and are still increasing. To determine the genetic relatedness of Bordetella pertussis strains, we compared multilocus variable-number tandem-repeat analysis (MLVA) results for isolates from China with those from Western countries. Among 335 isolates from China, the most common virulence-associated genotype was ptxA1/ptxC1/ptxP1/prn1/fim2–1/fim3A/tcfA2, which was more frequent among isolates from northern than southern China. Isolates of this genotype were highly resistant to erythromycin. We identified 36 ptxP3 strains mainly harboring ptxA1 and prn2 (35/36); ptxP3 strains were sensitive to erythromycin and were less frequently from northern China. For all isolates, the sulfamethoxazole/trimethoprim MIC was low, indicating that this drug should be recommended for patients infected with erythromycin-resistant B. pertussis. MLVA of 150 clinical isolates identified 13 MLVA types, including 3 predominant types. Our results show that isolates circulating in China differ from those in Western countries.
KW - Bordetella pertussis
KW - antibiotic sensitivity
KW - antimicrobial sensitivity
KW - macrolide resistance
KW - virulence-related genotype
KW - ptxP1
KW - bacteria
KW - China
KW - antimicrobial resistance
DO - 10.3201/eid2512.181836
UR - https://wwwnc.cdc.gov/eid/article/25/12/18-1836_article
ER - End of Reference