TY - JOUR AU - Quan, Chuansong AU - Wang, Qianli AU - Zhang, Jie AU - Zhao, Min AU - Dai, Qigang AU - Huang, Ting AU - Zhang, Zewu AU - Mao, Shenghua AU - Nie, Yifei AU - Liu, Jun AU - Xie, Yun AU - Zhang, Baorong AU - Bi, Yuhai AU - Shi, Weifeng AU - Liu, Peipei AU - Wang, Dayan AU - Feng, Luzhao AU - Yu, Hongjie AU - Liu, William AU - Gao, George T1 - Avian Influenza A Viruses among Occupationally Exposed Populations, China, 2014–2016 T2 - Emerging Infectious Disease journal PY - 2019 VL - 25 IS - 12 SP - 2215 SN - 1080-6059 AB - To determine the seroprevalence and seroconversion of avian influenza virus (AIV) antibodies in poultry workers, we conducted a seroepidemiologic study in 7 areas of China during December 2014–April 2016. We used viral isolation and reverse transcription PCR to detect AIVs in specimens from live poultry markets. We analyzed 2,124 serum samples obtained from 1,407 poultry workers by using hemagglutination inhibition and microneutralization assays. We noted seroprevalence of AIV antibodies for subtypes H9N2, H7N9, H6N1, H5N1-SC29, H5N6, H5N1-SH199, and H6N6. In serum from participants with longitudinal samples, we noted seroconversion, with >4-fold rise in titers, for H9N2, H7N9, H6N1, H5N1-SC29, H6N6, H5N6, and H5N1-SH199 subtypes. We found no evidence of H10N8 subtype. The distribution of AIV antibodies provided evidence of asymptomatic infection. We found that AIV antibody prevalence in live poultry markets correlated with increased risk for H7N9 and H9N2 infection among poultry workers. KW - seroepidemiologic study KW - seroprevalence KW - avian influenza virus KW - poultry worker KW - viruses KW - China KW - seroepidemiology KW - influenza KW - influenza A KW - occupational health KW - respiratory infections KW - zoonoses DO - 10.3201/eid2512.190261 UR - https://wwwnc.cdc.gov/eid/article/25/12/19-0261_article ER - End of Reference