TY - JOUR AU - Philpott, David C.E. AU - Nolan, Melissa AU - Evert, Nicole AU - Mayes, Bonny AU - Hesalroad, Dawn AU - Fonken, Eric AU - Murray, Kristy T1 - Acute and Delayed Deaths after West Nile Virus Infection, Texas, USA, 2002–2012 T2 - Emerging Infectious Disease journal PY - 2019 VL - 25 IS - 2 SP - 256 SN - 1080-6059 AB - Infection with West Nile virus (WNV) has a well-characterized acute disease process. However, long-term consequences are less understood. We searched death records for 4,142 residents of Texas, USA, infected with WNV during 2002–2012 and identified 557 (13%) deaths. We analyzed all-cause and cause-specific deaths after WNV infection by calculating standardized mortality ratios and using statewide mortality data. Acute-phase deaths (<90 days after symptom onset) occurred in 289 (7%) of case-patients; of those deaths, 289 (92%) were cases of West Nile neuroinvasive disease (WNND). Convalescent-phase deaths (>90 days after symptom onset) occurred in 268 (7%) of the remaining 3,853 case-patients; 210 (78%) of these deaths occurred in patients with WNND. Convalescent-phase WNND case-patients showed excess deaths from infectious and renal causes; case-patients <60 years of age had increased risk for all-cause death, specifically from renal, infectious, digestive, and circulatory causes. We provide population-level evidence of increased risk for death after WNV infection resulting in WNND. KW - West Nile virus KW - viruses KW - WNV KW - West Nile neuroinvasive disease KW - WNND KW - meningitis/encephalitis KW - acute deaths KW - delayed deaths KW - standardized mortality ratios KW - hazard ratios KW - survival analysis KW - Texas KW - United States DO - 10.3201/eid2502.181250 UR - https://wwwnc.cdc.gov/eid/article/25/2/18-1250_article ER - End of Reference