TY - JOUR AU - Osman, Muhammad AU - Harausz, Elizabeth AU - Garcia-Prats, Anthony AU - Schaaf, H. Simon AU - Moore, Brittany AU - Hicks, Robert AU - Achar, Jay AU - Amanullah, Farhana AU - Barry, Pennan AU - Becerra, Mercedes AU - Chiotan, Domnica AU - Drobac, Peter AU - Flood, Jennifer AU - Furin, Jennifer AU - Gegia, Medea AU - Isaakidis, Petros AU - Mariandyshev, Andrei AU - Ozere, Iveta AU - Shah, N. Sarita AU - Skrahina, Alena AU - Yablokova, Elena AU - Seddon, James AU - Hesseling, Anneke T1 - Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis T2 - Emerging Infectious Disease journal PY - 2019 VL - 25 IS - 3 SP - 441 SN - 1080-6059 AB - Extensively drug-resistant tuberculosis (XDR TB) has extremely poor treatment outcomes in adults. Limited data are available for children. We report on clinical manifestations, treatment, and outcomes for 37 children (<15 years of age) with bacteriologically confirmed XDR TB in 11 countries. These patients were managed during 1999–2013. For the 37 children, median age was 11 years, 32 (87%) had pulmonary TB, and 29 had a recorded HIV status; 7 (24%) were infected with HIV. Median treatment duration was 7.0 months for the intensive phase and 12.2 months for the continuation phase. Thirty (81%) children had favorable treatment outcomes. Four (11%) died, 1 (3%) failed treatment, and 2 (5%) did not complete treatment. We found a high proportion of favorable treatment outcomes among children, with mortality rates markedly lower than for adults. Regimens and duration of treatment varied considerably. Evaluation of new regimens in children is required. KW - tuberculosis and other mycobacteria KW - tuberculosis KW - TB KW - extensively drug-resistant tuberculosis KW - XDR TB KW - antimicrobial resistance KW - outcomes KW - mortality KW - meta-analysis KW - treatment outcomes KW - global systematic review KW - children KW - multidrug-resistant TB KW - MDR TB KW - bacteria KW - respiratory infections DO - 10.3201/eid2503.180852 UR - https://wwwnc.cdc.gov/eid/article/25/3/18-0852_article ER - End of Reference