TY - JOUR AU - Nelson, Christina AU - Murua, Christian AU - Jones, Jefferson AU - Mohler, Kelli AU - Zhang, Ying AU - Wiggins, Landon AU - Kwit, Natalie AU - Respicio-Kingry, Laurel AU - Kingry, Luke AU - Petersen, Jeannine AU - Brown, Jennifer AU - Aslam, Saima AU - Krafft, Melissa AU - Asad, Shadaba AU - Dagher, Hikmat AU - Ham, John AU - Medina-Garcia, Luis AU - Burns, Kevin AU - Kelley, Walter AU - Hinckley, Alison AU - Annambhotla, Pallavi AU - Carifo, Karen AU - Gonzalez, Anthony AU - Helsel, Elizabeth AU - Iser, Joseph AU - Johnson, Michael AU - Fritz, Curtis AU - Basavaraju, Sridhar T1 - Francisella tularensis Transmission by Solid Organ Transplantation, 2017 T2 - Emerging Infectious Disease journal PY - 2019 VL - 25 IS - 4 SP - 767 SN - 1080-6059 AB - In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died. Tularemia was suspected only after blood cultures from the surviving kidney recipient grew Francisella species. The organ donor, a middle-aged man from the southwestern United States, had been hospitalized for acute alcohol withdrawal syndrome, pneumonia, and multiorgan failure. F. tularensis subsp. tularensis (clade A2) was cultured from archived spleen tissue from the donor and blood from both kidney recipients. Whole-genome multilocus sequence typing indicated that the isolated strains were indistinguishable. The heart recipient remained seronegative with negative blood cultures but had been receiving antimicrobial drugs for a medical device infection before transplant. Two lagomorph carcasses collected near the donor’s residence were positive by PCR for F. tularensis subsp. tularensis (clade A2). This investigation documents F. tularensis transmission by solid organ transplantation. KW - Tularemia KW - Francisella tularensis KW - transplant KW - tissue donors KW - kidney transplantation/adverse effects KW - biological warfare KW - laboratory infection/prevention and KW - transplantation KW - laboratory infection KW - prevention and control KW - bacteria KW - United States KW - bioterrorism and preparedness DO - 10.3201/eid2504.181807 UR - https://wwwnc.cdc.gov/eid/article/25/4/18-1807_article ER - End of Reference