TY - JOUR AU - Thorlacius-Ussing, Louise AU - Sandholdt, Haakon AU - Larsen, Anders Rhod AU - Petersen, Andreas AU - Benfield, Thomas T1 - Age-Dependent Increase in Incidence of Staphylococcus aureus Bacteremia, Denmark, 2008–2015 T2 - Emerging Infectious Disease journal PY - 2019 VL - 25 IS - 5 SP - 875 SN - 1080-6059 AB - Staphylococcus aureus bacteremia (SAB) is a major cause of illness and death worldwide. We analyzed temporal trends of SAB incidence and death in Denmark during 2008–2015. SAB incidence increased 48%, from 20.76 to 30.37 per 100,000 person-years, during this period (p<0.001). The largest change in incidence was observed for persons >80 years of age: a 90% increase in the SAB rate (p<0.001). After adjusting for demographic changes, annual rates increased 4.0% (95% CI 3.0–5.0) for persons <80 years of age, 8.4% (95% CI 7.0–11.0) for persons 80–89 years of age, and 13.0% (95% CI 9.0–17.5) for persons >90 years of age. The 30-day case-fatality rate remained stable at 24%; crude population death rates increased by 53% during 2008–2015 (p<0.001). Specific causes and mechanisms for this rapid increase in SAB incidence among the elderly population remain to be clarified. KW - bacteremia KW - Staphylococcus aureus KW - incidence KW - population KW - epidemiology KW - bacteria KW - Denmark KW - aging KW - elderly KW - staphylococci DO - 10.3201/eid2505.181733 UR - https://wwwnc.cdc.gov/eid/article/25/5/18-1733_article ER - End of Reference