TY - JOUR AU - Ford, Laura AU - Ingle, Danielle AU - Glass, Kathryn AU - Veitch, Mark AU - Williamson, Deborah AU - Harlock, Michelle AU - Gregory, Joy AU - Stafford, Russell AU - French, Nigel AU - Bloomfield, Samuel AU - Grange, Zoe AU - Conway, Mary Lou AU - Kirk, Martyn T1 - Whole-Genome Sequencing of Salmonella Mississippi and Typhimurium Definitive Type 160, Australia and New Zealand T2 - Emerging Infectious Disease journal PY - 2019 VL - 25 IS - 9 SP - 1690 SN - 1080-6059 AB - We used phylogenomic and risk factor data on isolates of Salmonella enterica serovars Mississippi and Typhimurium definitive type 160 (DT160) collected from human, animal, and environmental sources to elucidate their epidemiology and disease reservoirs in Australia and New Zealand. Sequence data suggested wild birds as a likely reservoir for DT160; animal and environmental sources varied more for Salmonella Mississippi than for Salmonella Typhimurium. Australia and New Zealand isolates sat in distinct clades for both serovars; the median single-nucleotide polymorphism distance for DT160 was 29 (range 8–66) and for Salmonella Mississippi, 619 (range 565–737). Phylogenomic data identified plausible sources of human infection from wildlife and environmental reservoirs and provided evidence supporting New Zealand–acquired DT160 in a group of travelers returning to Australia. Wider use of real-time whole-genome sequencing in new locations and for other serovars may identify sources and routes of transmission, thereby aiding prevention and control. KW - Salmonella KW - genomics KW - epidemiology KW - humans KW - animals KW - zoonoses KW - birds KW - drinking water KW - Australia KW - Tasmania KW - New Zealand KW - bacteria KW - whole-genome sequencing KW - food safety DO - 10.3201/eid2509.181811 UR - https://wwwnc.cdc.gov/eid/article/25/9/18-1811_article ER - End of Reference