Diagnosis of Syphilitic Bilateral Papillitis Mimicking Papilloedema

Syphilis produces myriad nonspecific signs and symptoms. For example, optic disk swelling might be seen in patients with syphilis as a result of cranial hypertension (papilloedema), inflammatory optic neuritis with papillitis, or optic perineuritis. We report a case involving differential diagnosis of syphilitic bilateral papillitis mimicking papilloedema.


S yphilis, caused by infection with the bacterium
Treponema pallidum, is a sexually transmitted infection for which incidence has been increasing since 2002, especially among adult men >55 years of age who engage in risky sex (1). Syphilis has earned its nickname, the "great masquerader," because it produces myriad nonspecific signs and symptoms that make it difficult to distinguish from certain other diseases. Eye impairment occurs in >3% of cases (2,3) and can be the first manifestation (4). Optic nerve involvement, either unilateral or bilateral, in the form of papilloedema, perineuritis, or optic neuritis, is the second most common type of syphilitic ocular impairment (5). Each of these conditions shares findings from fundoscopy testing with unilateral or bilateral optic disk swelling (Table), but the etiology and, therefore, the diagnostic algorithm are different. Semiology and ophthalmological findings are the key to achieving a correct syndromic diagnosis.
We describe the case of a 62-year-old man who was admitted to the neurology department at Hospital Universitario de la Princesa in Madrid, Spain, with a 4-day history of bilateral decreased visual acuity. He was obese, an active smoker, and dyslipidemic. He reported neither ocular pain nor dyschromatopsia suggestive of optic neuritis, nor headache or diplopia usually associated with intracranial hypertension. He had no known history of syphilis. Visual acuity was 20/32 in the right eye and 20/63 in the left. Pupils were equal and reactive to light, with no relative afferent pupillary defect, which is typical of unilateral optic neuritis. Slit lamp examination results were normal, showing no inflamed cells in the anterior chambers or vitreous. Neurologic examination was normal. Opening pressure of the cerebrospinal fluid (CSF) on lumbar puncture was 27 cm H 2 O, above the reference range of 5-20 cm H 2 O. The CSF white cell count was 0, with normal glucose and protein levels. A fundus examination revealed bilateral optic disk swelling and peripapillary retinitis; visual field testing revealed bilateral central scotoma and an enlarged blind spot (Appendix, https://wwwnc.cdc. gov/EID/article/26/1/19-1122-App1.pdf).
Doctors initiated acetazolamide for suspected idiopathic intracranial hypertension (IIH), but visual acuity decreased to 20/40 in the right eye and 20/200 in the left. The rapid decrease in visual acuity and the lack of response to acetazolamide suggested optic nerve involvement, which seemed atypical for IIH in the absence of other cranial nerve impairment (being the sixth cranial nerve, which is most likely to be affected IIH in the first place).
A cerebral magnetic resonance imaging scan with gadolinium did not reveal any structural lesion or indirect findings of IIH. For this reason, the diagnostic study was expanded. Optical coherence tomography of the nerve fiber layer showed an increase in average thickness in both eyes, reflecting optic nerve edema. Results from laboratory tests for complete blood count, urea, electrolytes, enzymes, hormones, antinuclear antibodies, and protein electrophoresis were within normal ranges. Test results were negative for HIV. A treponemal test reacted negatively to a nontreponemal Venereal Disease Research Laboratory (VDRL) test in serum, but a VDRL test in CSF was reactive without dilution. Treatment with intravenous penicillin G (4 × 10 6 U, every 8 h for 14 d) was initiated. Fundoscopy results were normal, visual acuity remained stable but unimproved (0/40 in the right eye and 20/200 in the left eye, which was not unexpected), and visual fields remained stable 3 months after penicillin treatment was begun (Appendix). Lumbar puncture at that time revealed normal opening pressure and negative results for VDRL test scores.
Papilloedema refers to optic disk edema caused by increased intracranial pressure. The initial pressure of 27 cm H 2 O for this patient, despite being high, was lower than the 28 cm H 2 O in obese patients required to diagnose IIH, according to the latest International Classification of Headache Disorders standards (6). Syphilitic optic perineuritis is usually asymptomatic (7) because the inflammation is restricted to the optic nerve sheath, rather than the nerve itself (8). Clinical suspicion of that condition arises in the presence of optic disk swelling with normal CSF pressure and visual acuity (9). Optic neuritis, unlike these other conditions, is usually accompanied by rapid visual failure, as seen in this patient. Ocular pain is a common finding but not necessary for diagnosis.
Because the optic nerve and retina are considered extensions of the central nervous system, patients with ocular syphilis should undergo lumbar puncture and CSF analysis to confirm neurologic involvement. Diagnosing neurosyphilis relies on a combination of symptoms and signs verified by laboratory studies of blood and CSF (10), ocular symptoms due to bilateral papillitis, and positive treponemal test in serum and VDRL in CSF. This patient met these criteria.
Our findings underline that IIH can only be diagnosed through systematic exclusion of alternative diagnoses and the diagnosis cannot be reached by fundoscopy findings alone. Clinical findings are key points for differentiating papilloedema and ocular perineuritis from papillitis. A complete diagnostic work up is required to rule out all other etiologic causes of optic neuropathy and, if the diagnosis of ocular syphilis is reached, a lumbar puncture should be performed to rule out neurosyphilis.

About the Author
Dr. Gonzalez-Martinez is currently completing her residency in neurology at Hospital Universitario de la Princesa, Madrid. She has previously worked at 172 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 26, No. 1, January 2020 Dromedary camel populations, estimated to be 30 million globally, can be found in parts of Africa, the Middle East, and Central Asia, often in close proximity to humans. An equine influenza A(H3N8) virus (2) and human influenza A/USSR/90/77(H1N1)-like viruses (which were associated with fatal disease in 1980-1983) (3) have been isolated from Bactrian camels in Mongolia. However, little is known of influenza A virus infections in dromedary populations.

RESEARCH LETTERS
We examined nasal swabs and serum samples acquired from dromedary camels in Nigeria and Ethiopia during 2015-2017 for evidence of influenza virus infection. We detected antibodies against influenza A(H1N1) and A(H3N2) viruses and isolated an influenza A(H1N1) pdm09-like virus from a camel in Nigeria. Influenza surveillance in dromedary camels is needed.