TY - JOUR AU - Wei, Feixue AU - Su, Yingying AU - Cui, Xuelian AU - Yu, Xiaojuan AU - Li, Yafei AU - Song, Qiaoqiao AU - Yin, Kai AU - Huang, Shoujie AU - Li, Mingqiang AU - Zhang, Jun AU - Wu, Ting AU - Xia, Ningshao T1 - Sequential Acquisition of Human Papillomavirus Infection at Genital and Anal Sites, Liuzhou, China T2 - Emerging Infectious Disease journal PY - 2020 VL - 26 IS - 10 SP - 2387 SN - 1080-6059 AB - Little is known about the risk for acquiring a concordant human papillomavirus (HPV) infection in a genital (or anal) site after an anal (or genital) HPV infection. We collected 3 sets of anogenital specimens at 6-month intervals from 2,309 men and 2,378 women in Liuzhou, China, and tested these specimens for HPV. The risk for sequential anal HPV infection in participants with a previous genital HPV infection was higher than for participants without an infection (hazard ratio [HR] 4.4, 95% CI 3.4–5.8 for women and HR 2.6, 95% CI 1.4–4.6 for men). For sequential genital HPV infection, women with a previous anal infection had a higher risk (HR 1.9, 95% CI 1.2–3.1), but no major difference was found for men (HR 0.7, 95% CI 0.2–1.9). Our study indicates that autoinoculation might play a major role in anogenital HPV transmission, in addition to direct sexual intercourse, especially for anal infection in women. KW - human papillomavirus KW - HPV KW - viruses KW - genital sites KW - anal sites KW - sequential infection KW - infection KW - sexually transmitted infections KW - observational cohort study KW - China KW - autoinoculation DO - 10.3201/eid2610.191646 UR - https://wwwnc.cdc.gov/eid/article/26/10/19-1646_article ER - End of Reference