TY - JOUR AU - Holmes, Alex AU - Tildesley, Michael AU - Solomon, Anthony AU - Mabey, David C.W. AU - Sokana, Oliver AU - Marks, Michael AU - Dyson, Louise T1 - Modeling Treatment Strategies to Inform Yaws Eradication T2 - Emerging Infectious Disease journal PY - 2020 VL - 26 IS - 11 SP - 2685 SN - 1080-6059 AB - Yaws is a neglected tropical disease targeted for eradication by 2030. To achieve eradication, finding and treating asymptomatic infections as well as clinical cases is crucial. The proposed plan, the Morges strategy, involves rounds of total community treatment (i.e., treating the whole population) and total targeted treatment (TTT) (i.e., treating clinical cases and contacts). However, modeling and empirical work suggests asymptomatic infections often are not found in the same households as clinical cases, reducing the utility of household-based contact tracing for a TTT strategy. We use a model fitted to data from the Solomon Islands to predict the likelihood of elimination of transmission under different intervention schemes and levels of systematic nontreatment resulting from the intervention. Our results indicate that implementing additional treatment rounds through total community treatment is more effective than conducting additional rounds of treatment of at-risk persons through TTT. KW - yaws KW - mass drug administration KW - Treponema pallidum pertenue KW - contact tracing KW - bacteria KW - bacterial infections KW - neglected tropical diseases KW - modeling KW - Solomon Islands KW - Treponema pallidum KW - TPE DO - 10.3201/eid2611.191491 UR - https://wwwnc.cdc.gov/eid/article/26/11/19-1491_article ER - End of Reference