TY - JOUR AU - Shah, Melisa AU - Ndenga, Bryson AU - Mutuku, Francis AU - Vu, David AU - Grossi-Soyster, Elysse AU - Okuta, Victoria AU - Ronga, Charles AU - Chebii, Philip AU - Maina, Priscilla AU - Jembe, Zainab AU - Bosire, Carren AU - Amugongo, Jael AU - Sahoo, Malaya AU - Huang, ChunHong AU - Weber, Jenna AU - Edgerton, Sean AU - Hortion, Jimmy AU - Bennett, Shannon AU - Pinsky, Benjamin AU - LaBeaud, A. Desiree T1 - High Dengue Burden and Circulation of 4 Virus Serotypes among Children with Undifferentiated Fever, Kenya, 2014–2017 T2 - Emerging Infectious Disease journal PY - 2020 VL - 26 IS - 11 SP - 2638 SN - 1080-6059 AB - Little is known about the extent and serotypes of dengue viruses circulating in Africa. We evaluated the presence of dengue viremia during 4 years of surveillance (2014–2017) among children with febrile illness in Kenya. Acutely ill febrile children were recruited from 4 clinical sites in western and coastal Kenya, and 1,022 participant samples were tested by using a highly sensitive real-time reverse transcription PCR. A complete case analysis with genomic sequencing and phylogenetic analyses was conducted to characterize the presence of dengue viremia among participants during 2014–2017. Dengue viremia was detected in 41.9% (361/862) of outpatient children who had undifferentiated febrile illness in Kenya. Of children with confirmed dengue viremia, 51.5% (150/291) had malaria parasitemia. All 4 dengue virus serotypes were detected, and phylogenetic analyses showed several viruses from novel lineages. Our results suggests high levels of dengue virus infection among children with undifferentiated febrile illness in Kenya. KW - dengue KW - dengue virus KW - viruses KW - arboviruses KW - serotypes KW - disease burden KW - circulation KW - children KW - undifferentiated fever KW - zoonoses KW - Kenya DO - 10.3201/eid2611.200960 UR - https://wwwnc.cdc.gov/eid/article/26/11/20-0960_article ER - End of Reference