TY - JOUR AU - Gallian, Pierre AU - Lhomme, Sébastien AU - Morel, Pascal AU - Gross, Sylvie AU - Mantovani, Carole AU - Hauser, Lisette AU - Tinard, Xavier AU - Pouchol, Elodie AU - Djoudi, Rachid AU - Assal, Azzedine AU - Abravanel, Florence AU - Izopet, Jacques AU - Tiberghien, Pierre T1 - Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated Plasma T2 - Emerging Infectious Disease journal PY - 2020 VL - 26 IS - 12 SP - 2881 SN - 1080-6059 AB - Hepatitis E has emerged as a major transfusion-transmitted infectious risk. Two recipients of plasma from 2 lots (A and B) of pooled solvent/detergent–treated plasma were found to be infected by hepatitis E virus (HEV) that was determined to have been transmitted by the solvent/detergent–treated plasma. HEV RNA viral loads were 433 IU in lot A and 55 IU in lot B. Retrospective studies found that 100% (13/13) of evaluable lot A recipients versus 18% (3/17) of evaluable lot B recipients had been infected by HEV (p<0.001), albeit not necessarily at time of transfusion. Among evaluable recipients, 86% with a transfused HEV RNA load >50,000 IU were infected, most likely by the HEV-containing solvent/detergent–treated plasma, versus only 7% with a transfused HEV RNA load <50,000 IU (p<0.001). Overall, solvent/detergent–treated plasma might harbor HEV. Such an occurrence might result in a dose-dependent risk for transfusion-transmitted hepatitis E. KW - hepatitis E virus KW - HEV KW - viruses KW - transmission KW - solvent/detergent–treated plasma KW - plasma KW - retrospective study KW - infectious dose KW - blood donors KW - zoonoses KW - France DO - 10.3201/eid2612.191482 UR - https://wwwnc.cdc.gov/eid/article/26/12/19-1482_article ER - End of Reference