TY - JOUR AU - Tam, Clarence AU - Yeo, Kee Thai AU - Tee, Nancy AU - Lin, Raymond AU - Mak, Tze Minn AU - Thoon, Koh Cheng AU - Jit, Mark AU - Yung, Chee Fu T1 - Burden and Cost of Hospitalization for Respiratory Syncytial Virus in Young Children, Singapore T2 - Emerging Infectious Disease journal PY - 2020 VL - 26 IS - 7 SP - 1489 SN - 1080-6059 AB - Respiratory syncytial virus (RSV) is the most common cause of pediatric acute lower respiratory tract infection worldwide. Detailed data on the health and economic burden of RSV disease are lacking from tropical settings with year-round RSV transmission. We developed a statistical and economic model to estimate the annual incidence and healthcare cost of medically attended RSV disease among young children in Singapore, using Monte Carlo simulation to account for uncertainty in model parameters. RSV accounted for 708 hospitalizations in children <6 months of age (33.5/1,000 child-years) and 1,096 in children 6–29 months of age (13.2/1,000 child-years). The cost of hospitalization was SGD 5.7 million (US $4.3 million) at 2014 prices; patients bore 60% of the cost. RSV-associated disease burden in tropical settings in Asia is high and comparable to other settings. Further work incorporating efficacy data from ongoing vaccine trials will help to determine the potential cost-effectiveness of different vaccination strategies. KW - respiratory syncytial virus KW - respiratory infections KW - lower respiratory tract infection KW - pneumonia KW - bronchiolitis KW - disease burden KW - economic cost KW - economic modeling KW - viruses KW - Singapore DO - 10.3201/eid2607.190539 UR - https://wwwnc.cdc.gov/eid/article/26/7/19-0539_article ER - End of Reference