TY - JOUR AU - Hierweger, Melanie AU - Koch, Michel AU - Rupp, Melanie AU - Maes, Piet AU - Di Paola, Nicholas AU - Bruggmann, Rémy AU - Kuhn, Jens AU - Schmidt-Posthaus, Heike AU - Seuberlich, Torsten T1 - Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017 T2 - Emerging Infectious Disease journal PY - 2021 VL - 27 IS - 12 SP - 3082 SN - 1080-6059 AB - European perch (Perca fluviatilis) are increasingly farmed as a human food source. Viral infections of European perch remain largely unexplored, thereby putting farm populations at incalculable risk for devastating fish epizootics and presenting a potential hazard to consumers. To address these concerns, we applied metatranscriptomics to identify disease-associated viruses in European perch farmed in Switzerland. Unexpectedly, in clinically diseased fish we detected novel freshwater fish filoviruses, a novel freshwater fish hantavirus, and a previously unknown rhabdovirus. Hantavirus titers were high, and we demonstrated virus in macrophages and gill endothelial cells by using in situ hybridization. Rhabdovirus titers in organ samples were low, but virus could be isolated on cell culture. Our data add to the hypothesis that filoviruses, hantaviruses, and rhabdoviruses are globally distributed common fish commensals, pathogens, or both. Our findings shed new light on negative-sense RNA virus diversity and evolution. KW - European perch KW - filovirus KW - hantavirus KW - rhabdovirus KW - freshwater fish KW - viruses KW - Switzerland DO - 10.3201/eid2712.210491 UR - https://wwwnc.cdc.gov/eid/article/27/12/21-0491_article ER - End of Reference