TY - JOUR AU - Pomar, Léo AU - Lambert, Véronique AU - Matheus, Séverine AU - Pomar, Céline AU - Hcini, Najeh AU - Carles, Gabriel AU - Rousset, Dominique AU - Vouga, Manon AU - Panchaud, Alice AU - Baud, David T1 - Prolonged Maternal Zika Viremia as a Marker of Adverse Perinatal Outcomes T2 - Emerging Infectious Disease journal PY - 2021 VL - 27 IS - 2 SP - 490 SN - 1080-6059 AB - Whether prolonged maternal viremia after Zika virus infection represents a risk factor for maternal–fetal transmission and subsequent adverse outcomes remains unclear. In this prospective cohort study in French Guiana, we enrolled Zika virus–infected pregnant women with a positive PCR result at inclusion and noninfected pregnant women; both groups underwent serologic testing in each trimester and at delivery during January–July 2016. Prolonged viremia was defined as ongoing virus detection >30 days postinfection. Adverse outcomes (fetal loss or neurologic anomalies) were more common in fetuses and neonates from mothers with prolonged viremia (40.0%) compared with those from infected mothers without prolonged viremia (5.3%, adjusted relative risk [aRR] 7.2 [95% CI 0.9–57.6]) or those from noninfected mothers (6.6%, aRR 6.7 [95% CI 3.0–15.1]). Congenital infections were confirmed more often in fetuses and neonates from mothers with prolonged viremia compared with the other 2 groups (60.0% vs. 26.3% vs. 0.0%, aRR 2.3 [95% CI 0.9–5.5]). KW - Zika KW - prolonged viremia KW - congenital infection KW - congenital Zika syndrome KW - viruses KW - mosquitoborne diseases KW - vector-borne infections KW - French Guiana KW - Zika virus KW - ZIKV DO - 10.3201/eid2702.200684 UR - https://wwwnc.cdc.gov/eid/article/27/2/20-0684_article ER - End of Reference