TY - JOUR AU - Joffret, Marie-Line AU - Doté, Joël Wilfried AU - Gumede, Nicksy AU - Vignuzzi, Marco AU - Bessaud, Maël AU - Gouandjika-Vasilache, Ionela T1 - Vaccine-Derived Polioviruses, Central African Republic, 2019 T2 - Emerging Infectious Disease journal PY - 2021 VL - 27 IS - 2 SP - 620 SN - 1080-6059 AB - Since May 2019, the Central African Republic has experienced a poliomyelitis outbreak caused by type 2 vaccine-derived polioviruses (VDPV-2s). The outbreak affected Bangui, the capital city, and 10 districts across the country. The outbreak resulted from several independent emergence events of VDPV-2s featuring recombinant genomes with complex mosaic genomes. The low number of mutations (<20) in the viral capsid protein 1–encoding region compared with the vaccine strain suggests that VDPV-2 had been circulating for a relatively short time (probably <3 years) before being isolated. Environmental surveillance, which relies on a limited number of sampling sites in the Central African Republic and does not cover the whole country, failed to detect the circulation of VDPV-2s before some had induced poliomyelitis in children. KW - Poliovirus KW - oral polio vaccine KW - vaccine-derived poliovirus KW - poliomyelitis KW - eradication KW - viruses KW - Central African Republic DO - 10.3201/eid2702.203173 UR - https://wwwnc.cdc.gov/eid/article/27/2/20-3173_article ER - End of Reference