Retrospective Study of Kyasanur Forest Disease and Deaths among Nonhuman Primates, India, 1957–2020

Kyasanur Forest disease (KFD) is a tickborne hemorrhagic disease affecting primates along the Western Ghats mountain range in India. Our retrospective study indicated that >3,314 monkey deaths attributed to KFD were reported in KFD-endemic states in India during 1957–2020. These data can help guide surveillance to protect animal and human health.

Of the reported monkey deaths, a total of 1,676 deaths occurred in S. entellus monkeys and 400 deaths occurred in M. radiata monkeys; species were not reported for the remaining 1,238 deaths.
We found an early report of KFD in monkeys outside of Karnataka in Tamil Nadu state in 2012, which could be linked to an outbreak of human cases at the Bandipur Tiger Reserve in 2012. Monkeys from Karnataka might have entered Tamil Nadu carrying the virus or infected ticks. Subsequently, KFD in monkeys was reported in Kerala state in 2014 and Goa and Maharashtra states in 2016. Substantial overlap occurred between reported monkey deaths and human cases of KFD ( Figure 2). We identified the drivers behind KFD transmission and geographic expansion based on the literature (Table 2).
Higher mortality rates occurred among S. entellus monkeys (81% of 1,159 deaths) than among M. radiata monkeys during 1957-1964 (7). Most monkey deaths were reported in evergreen and semievergreen forests in the Western Ghats (8). We found no other information associating the frequency of monkey deaths to habitat.
The abundance of these primate species in the area of interest is difficult to determine because of limited studies with inconsistent sampling methods. In Karnataka, higher encounter rates with M. radiata monkeys were reported in wet evergreen forests and human-inhabited areas (9). M. radiata monkeys were encountered mainly in the Western Ghats and the Southern Plateau, whereas S. entellus monkeys were abundant in the Western Ghats and Northern Plains. Based on a 2001 Environmenta Information System bulletin (10), the national population of M. radiata monkeys in India was ≈150,000 and that of S. entellus monkeys was ≈300,000. Both species have suffered population decline because of habitat loss, translocation, and hunting, and minimal efforts have been undertaken to conserve these species (9,11).

Conclusions
Our study highlights the need for consistent surveillance of monkey deaths. Monkey deaths caused by KFDV are harbingers of human cases (1,3,4), making these animals potential sentinels for KFD (6). Therefore, determining these primate species' relative susceptibility to KFDV to evaluate the potential to use monkey deaths for surveillance is essential. In laboratory experiments, higher mortality rates have been reported in S. entellus than M. radiata monkeys (12) Most human cases of KFD are typically reported during December-May, the same period during which monkey deaths generally occur. Local public health authorities often undertake precautionary measures on the basis of monkey deaths, including spraying acaricide around areas with monkey carcasses and vaccination of persons within a 5-km radius (6,14). The importance of animals as sentinels of infectious diseases, environmental hazards, and acts of bioterrorism is well documented (15). Because monkey deaths are used as sentinels for KFD, establishing year-round surveillance systems that consistently report KFD-related monkey deaths by date, location, and species is essential to better understand the epidemiology of the disease and design appropriate public health measures.
One limitation of our review is the inconsistency and gaps in the availability of reported monkey deaths caused by KFD. Few studies report monkey mortality data or provide specific monkey deaths by location, year, and species, so assessing whether mortality rates have changed over time is difficult. Another limitation is the incomplete data on testing and diagnoses of monkey carcasses for KFDV because of challenges such as distance to the testing site and delays in discovery.

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Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 27, No. 7, July 2021 Further research is needed to develop serosurveys specific to KFDV among monkeys, determine species-specific vulnerability to KFDV, and assess whether KFDV can spread through routes other than tick transmission. Testing capacity in KFD-endemic states should be strengthened to conduct timely monkey necropsies, providing more information on the prevalence of KFD in these sentinel animals, to elucidate the epidemiology of KFDV and protect monkey and human health.

About the Author
Ms. Chakraborty is a doctoral candidate in the Program in Ecology Evolution and Conservation Biology at the University of Illinois, Urbana-Champaign. Her research interests include the ecology and epidemiology of vectorborne diseases and One Health approaches in disease surveillance and prevention.