TY - JOUR AU - Li, Yifan AU - Merbah, Mélanie AU - Wollen-Roberts, Suzanne AU - Beckman, Bradley AU - Mdluli, Thembi AU - Swafford, Isabella AU - Mayer, Sandra AU - King, Jocelyn AU - Corbitt, Courtney AU - Currier, Jeffrey AU - Liu, Heather AU - Esber, Allahna AU - Pinyakorn, Suteeraporn AU - Parikh, Ajay AU - Francisco, Leilani AU - Phanuphak, Nittaya AU - Maswai, Jonah AU - Owuoth, John AU - Kibuuka, Hannah AU - Iroezindu, Michael AU - Bahemana, Emmanuel AU - Vasan, Sandhya AU - Ake, Julie AU - Modjarrad, Kayvon AU - Gromowski, Gregory AU - Paquin-Proulx, Dominic AU - Rolland, Morgane T1 - Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand T2 - Emerging Infectious Disease journal PY - 2022 VL - 28 IS - 11 SP - 2214 SN - 1080-6059 AB - Prior immune responses to coronaviruses might affect human SARS-CoV-2 response. We screened 2,565 serum and plasma samples collected from 2013 through early 2020, before the COVID-19 pandemic began, from 2,250 persons in 4 countries in Africa (Kenya, Nigeria, Tanzania, and Uganda) and in Thailand, including persons living with HIV-1. We detected IgG responses to SARS-CoV-2 spike (S) subunit 2 protein in 1.8% of participants. Profiling against 23 coronavirus antigens revealed that responses to S, subunit 2, or subunit 1 proteins were significantly more frequent than responses to the receptor-binding domain, S-Trimer, or nucleocapsid proteins (p<0.0001). We observed similar responses in persons with or without HIV-1. Among all coronavirus antigens tested, SARS-CoV-2, SARS-CoV-1, and Middle East respiratory syndrome coronavirus antibody responses were much higher in participants from Africa than in participants from Thailand (p<0.01). We noted less pronounced differences for endemic coronaviruses. Serosurveys could affect vaccine and monoclonal antibody distribution across global populations. KW - COVID-19 KW - viruses KW - respiratory infections KW - severe acute respiratory syndrome coronavirus 2 KW - SARS-CoV-2 KW - SARS KW - coronavirus disease KW - zoonoses KW - coronavirus KW - serosurvey KW - HIV-1 KW - Africa KW - Thailand DO - 10.3201/eid2811.221041 UR - https://wwwnc.cdc.gov/eid/article/28/11/22-1041_article ER - End of Reference