TY - JOUR
AU - Le Ray, Laure Fournier
AU - Aubry, Alexandra
AU - Sougakoff, Wladimir
AU - Revest, Matthieu
AU - Robert, Jérôme
AU - Bonnet, Isabelle
AU - Veziris, Nicolas
AU - Morel, Florence
T1 - atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure
T2 - Emerging Infectious Disease journal
PY - 2022
VL - 28
IS - 5
SP - 1062
SN - 1080-6059
AB -
We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance.
KW - tuberculosis
KW - atpE
KW - bedaquiline
KW - MDR TB
KW - XDR TB
KW - Rv0678
KW - antimicrobial resistance
KW - bacteria
KW - tuberculosis and other mycobacteria
DO - 10.3201/eid2805.212517
UR - https://wwwnc.cdc.gov/eid/article/28/5/21-2517_article
ER - End of Reference