TY - JOUR AU - Le Ray, Laure Fournier AU - Aubry, Alexandra AU - Sougakoff, Wladimir AU - Revest, Matthieu AU - Robert, Jérôme AU - Bonnet, Isabelle AU - Veziris, Nicolas AU - Morel, Florence T1 - atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure T2 - Emerging Infectious Disease journal PY - 2022 VL - 28 IS - 5 SP - 1062 SN - 1080-6059 AB - We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance. KW - tuberculosis KW - atpE KW - bedaquiline KW - MDR TB KW - XDR TB KW - Rv0678 KW - antimicrobial resistance KW - bacteria KW - tuberculosis and other mycobacteria DO - 10.3201/eid2805.212517 UR - https://wwwnc.cdc.gov/eid/article/28/5/21-2517_article ER - End of Reference