TY - JOUR
AU - Shea, Joseph
AU - Smith, Carol
AU - Halse, Tanya
AU - Kohlerschmidt, Donna
AU - Rourke, Amy
AU - Musser, Kimberlee
AU - Escuyer, Vincent
AU - Lapierre, Pascal
T1 - Novel Mycobacterium tuberculosis Complex Genotype Related to M. caprae
T2 - Emerging Infectious Disease journal
PY - 2022
VL - 28
IS - 7
SP - 1431
SN - 1080-6059
AB -
We report the unusual genotypic characterization of a bacterium isolated from a clinical sample of a patient who grew up in Bangladesh and lives in the United States. Using whole-genome sequencing, we identified the bacterium as a member of the Mycobacterium tuberculosis complex (MTBC). Phylogenetic placement of this strain suggests a new MTBC genotype. Even though it had the same spoligotype as M. caprae strains, single-nucleotide polymorphism–based phylogenetic analysis placed the isolate as a sister lineage distinct from M. caprae, most closely related to 5 previously sequenced genomes isolated from primates and elephants in Asia. We propose a new animal-associated lineage, La4, within MTBC.
KW - Mycobacterium tuberculosis
KW - Mycobacterium tuberculosis complex
KW - bacteria
KW - tuberculosis and other mycobacteria
KW - genotypes
KW - animal-adapted
KW - MTBC lineages
KW - United States
DO - 10.3201/eid2807.212353
UR - https://wwwnc.cdc.gov/eid/article/28/7/21-2353_article
ER - End of Reference