TY - JOUR AU - Shea, Joseph AU - Smith, Carol AU - Halse, Tanya AU - Kohlerschmidt, Donna AU - Rourke, Amy AU - Musser, Kimberlee AU - Escuyer, Vincent AU - Lapierre, Pascal T1 - Novel Mycobacterium tuberculosis Complex Genotype Related to M. caprae T2 - Emerging Infectious Disease journal PY - 2022 VL - 28 IS - 7 SP - 1431 SN - 1080-6059 AB - We report the unusual genotypic characterization of a bacterium isolated from a clinical sample of a patient who grew up in Bangladesh and lives in the United States. Using whole-genome sequencing, we identified the bacterium as a member of the Mycobacterium tuberculosis complex (MTBC). Phylogenetic placement of this strain suggests a new MTBC genotype. Even though it had the same spoligotype as M. caprae strains, single-nucleotide polymorphism–based phylogenetic analysis placed the isolate as a sister lineage distinct from M. caprae, most closely related to 5 previously sequenced genomes isolated from primates and elephants in Asia. We propose a new animal-associated lineage, La4, within MTBC. KW - Mycobacterium tuberculosis KW - Mycobacterium tuberculosis complex KW - bacteria KW - tuberculosis and other mycobacteria KW - genotypes KW - animal-adapted KW - MTBC lineages KW - United States DO - 10.3201/eid2807.212353 UR - https://wwwnc.cdc.gov/eid/article/28/7/21-2353_article ER - End of Reference