TY - JOUR AU - Ko, Yura AU - Murayama, Hiroaki AU - Yamasaki, Lisa AU - Kinoshita, Ryo AU - Suzuki, Motoi AU - Nishiura, Hiroshi T1 - Age-Dependent Effects of COVID-19 Vaccine and of Healthcare Burden on COVID-19 Deaths, Tokyo, Japan T2 - Emerging Infectious Disease journal PY - 2022 VL - 28 IS - 9 SP - 1777 SN - 1080-6059 AB - COVID-19 vaccine effectiveness against death in Japan remains unknown. Furthermore, although evidence indicates that healthcare capacity influences case-fatality risk (CFR), it remains unknown whether this relationship is mediated by age. With a modeling study, we analyzed daily COVID-19 cases and deaths during January–August 2021 by using Tokyo surveillance data to jointly estimate COVID-19 vaccine effectiveness against death and age-specific CFR. We also examined daily healthcare operations to determine the association between healthcare burden and age-specific CFR. Among fully vaccinated patients, vaccine effectiveness against death was 88.6% among patients 60–69 years of age, 83.9% among patients 70–79 years of age, 83.5% among patients 80–89 years of age, and 77.7% among patients >90 years of age. A positive association of several indicators of healthcare burden with CFR among patients >70 years of age suggested an age-dependent effect of healthcare burden on CFR in Japan. KW - COVID-19 KW - 2019 novel coronavirus disease KW - coronavirus disease KW - severe acute respiratory syndrome coronavirus 2 KW - SARS-CoV-2 KW - viruses KW - respiratory infections KW - zoonoses KW - vaccine effectiveness against death KW - case-fatality risk KW - healthcare burden KW - vaccines KW - Japan DO - 10.3201/eid2809.220377 UR - https://wwwnc.cdc.gov/eid/article/28/9/22-0377_article ER - End of Reference