TY - JOUR AU - Loesche, Michael AU - Karlson, Elizabeth AU - Talabi, Opeyemi AU - Zhou, Guohai AU - Boutin, Natalie AU - Atchley, Rachel AU - Loevinsohn, Gideon AU - Chang, Jun Bai Park AU - Hasdianda, Mohammad AU - Okenla, Adetoun AU - Sampson, Elizabeth AU - Schram, Haley AU - Magsipoc, Karen AU - Goodman, Kirsten AU - Donahue, Lauren AU - MacGowan, Maureen AU - Novack, Lewis AU - Jarolim, Petr AU - Baden, Lindsey AU - Nilles, Eric T1 - Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies T2 - Emerging Infectious Disease journal PY - 2022 VL - 28 IS - 9 SP - 1859 SN - 1080-6059 AB - Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection in serologic surveys. However, longitudinal kinetics and seroreversion are poorly defined. We found substantial seroreversion of nucleocapsid total immunoglobulin, underscoring the need to account for seroreversion in seroepidemiologic studies. KW - SARS-CoV-2 KW - severe acute respiratory syndrome coronavirus 2 KW - coronaviruses KW - viruses KW - COVID-19 KW - coronavirus disease KW - respiratory infections KW - nucleocapsid antibody KW - longitudinal KW - kinetics KW - seroreversion KW - seroepidemiology KW - zoonoses DO - 10.3201/eid2809.220729 UR - https://wwwnc.cdc.gov/eid/article/28/9/22-0729_article ER - End of Reference