TY - JOUR AU - Ponderand, Léa AU - Guimard, Thomas AU - Lazaro, Estibaliz AU - Dupuy, Henry AU - Peuchant, Olivia AU - Roch, Nathalie AU - Deroche, Philippe AU - Ferry, Tristan AU - Maurin, Max AU - Hennebique, Aurélie AU - Boisset, Sandrine AU - Pelloux, Isabelle AU - Caspar, Yvan T1 - Case Studies and Literature Review of Francisella tularensis–Related Prosthetic Joint Infection T2 - Emerging Infectious Disease journal PY - 2023 VL - 29 IS - 6 SP - 1117 SN - 1080-6059 AB - Tularemia is a zoonotic infection caused by Francisella tularensis. Its most typical manifestations in humans are ulceroglandular and glandular; infections in prosthetic joints are rare. We report 3 cases of F. tularensis subspecies holarctica–related prosthetic joint infection that occurred in France during 2016–2019. We also reviewed relevant literature and found only 5 other cases of Francisella-related prosthetic joint infections worldwide, which we summarized. Among those 8 patients, clinical symptoms appeared 7 days to 19 years after the joint placement and were nonspecific to tularemia. Although positive cultures are typically obtained in only 10% of tularemia cases, strains grew in all 8 of the patients. F. tularensis was initially identified in 2 patients by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; molecular methods were used for 6 patients. Surgical treatment in conjunction with long-term antimicrobial treatment resulted in favorable outcomes; no relapses were seen after 6 months of follow-up. KW - tularemia KW - prosthetic joint infection KW - Francisella tularensis KW - zoonotic disease KW - zoonoses KW - bacteria KW - France DO - 10.3201/eid2906.221395 UR - https://wwwnc.cdc.gov/eid/article/29/6/22-1395_article ER - End of Reference