TY - JOUR AU - Rodríguez-Grande, Cristina AU - Estévez, Agustín AU - Palomino-Cabrera, Rosalía AU - Molero-Salinas, Andrea AU - Peñas-Utrilla, Daniel AU - Herranz, Marta AU - Sanz-Pérez, Amadeo AU - Alcalá, Luis AU - Veintimilla, Cristina AU - Catalán, Pilar AU - Martínez-Laperche, Carolina AU - Alonso, Roberto AU - Muñoz, Patricia AU - Pérez-Lago, Laura AU - de Viedma, Darío García T1 - Early SARS-CoV-2 Reinfections Involving the Same or Different Genomic Lineages, Spain T2 - Emerging Infectious Disease journal PY - 2023 VL - 29 IS - 6 SP - 1154 SN - 1080-6059 AB - Centers for Disease Control and Prevention guidelines consider SARS-CoV-2 reinfection when sequential COVID-19 episodes occur >90 days apart. However, genomic diversity acquired over recent COVID-19 waves could mean previous infection provides insufficient cross-protection. We used genomic analysis to assess the percentage of early reinfections in a sample of 26 patients with 2 COVID-19 episodes separated by 20–45 days. Among sampled patients, 11 (42%) had reinfections involving different SARS-CoV-2 variants or subvariants. Another 4 cases were probable reinfections; 3 involved different strains from the same lineage or sublineage. Host genomic analysis confirmed the 2 sequential specimens belonged to the same patient. Among all reinfections, 36.4% involved non-Omicron, then Omicron lineages. Early reinfections showed no specific clinical patterns; 45% were among unvaccinated or incompletely vaccinated persons, 27% were among persons <18 years of age, and 64% of patients had no risk factors. Time between sequential positive SARS-CoV-2 PCRs to consider reinfection should be re-evaluated. KW - COVID-19 KW - SARS-CoV-2 KW - respiratory infections KW - severe acute respiratory syndrome coronavirus 2 KW - SARS KW - coronavirus disease KW - zoonoses KW - viruses KW - coronavirus KW - Spain DO - 10.3201/eid2906.221696 UR - https://wwwnc.cdc.gov/eid/article/29/6/22-1696_article ER - End of Reference