Subdural Empyema from Streptococcus suis Infection, South Korea

In Jeju Island, South Korea, a patient who consumed raw pig products had subdural empyema, which led to meningitis, sepsis, and status epilepticus. We identified Streptococcus suis from blood and the subdural empyema. This case illustrates the importance of considering dietary habits in similar clinical assessments to prevent misdiagnosis.

S treptococcus suis is a zoonotic pathogen that affects pigs and humans when they handle pigs or eat undercooked pork products.Globally, an outbreak of infection occurred in China in 2005, and S. suis is a common cause of bacterial meningitis in Vietnam and Hong Kong (1,2).High-risk eating habits of ingesting raw or undercooked pork also have been reported in Thailand (2).
Although S. suis infection traditionally is associated with pig contact or consumption of undercooked pork, South Korea reported its first human infection in 2012, with subsequent cases not explicitly linked to pigs (3).Of note, consuming raw pork is rare in South Korea because of cultural taboos.In South Korea, the prevalence of S. suis infection was 12.6% among slaughtered pigs and 16.4% among diseased pigs; serotypes 2 and 14 were predominant in the Jeju area compared with other regions (4).
Common manifestations of S. suis infection are meningitis, endocarditis, septicemia, and arthritis but not subdural empyema (2).Subdural empyema is a rare but serious infection that causes a collection of pus between the dura and arachnoid layers of the meninges (5).We describe a case of subdural empyema caused by to S. suis infection after the consumption of raw pig products in Jeju Island, South Korea, where the pork industry has been an economic pillar for over 500 years.
The patient, a 76-year-old man, visited the emergency department exhibiting dysarthria, neck stiffness, and right-sided weakness with motor grade III.He did not have hearing loss, a common symptom of human S. suis infection, or signs of increased intracranial pressure such as papilledema.His medical history included a fall 3 months prior and recent headache and dizziness.Initial brain computed tomography and magnetic resonance imaging showed chronic subdural hematoma (cSDH) with recurrent bleeding and an inflamed subdural sac (Figure 1).Concurrently, he exhibited septic symptoms, such as fever, hypotension, marked thrombocytopenia, and elevated inflammatory markers, necessitating immediate administration of antibiotics (vancomycin, ceftazidime, and metronidazole).Further studies showed that he did not have endocarditis, sinusitis, or otitis media (all possible causes of subdural empyema) (5).We drew blood cultures on admission day and on hospital days 4 and 7 and incubated them for >5 days.On hospital day 4, we detected S. suis from a blood culture.Subsequent inquiries into the patient's dietary habits revealed recent consumption of Ae-Jeo-Hoe, a traditional dish from Jeju Island, made by slicing open the belly of a pregnant pig, finely chopping or grinding the fetus, and eating it raw with various seasonings.Consequently, we conducted further microbiologic investigations to rule out other conditions, such as severe fever with thrombocytopenia syndrome and cysticercosis, which all turned out negative.
On day 16, the patient had onset of convulsive status epilepticus potentially attributable to meningitis, which was managed by a continuous infusion of propofol.The patient was subsequently stabilized, and his neurologic symptoms improved.
This case is noteworthy because it represents a neurosurgical condition, specifically subdural empyema, which required surgery, associated with S. suis infection.In addition, severe conditions such as sepsis and status epilepticus after the infection underscore the lethality of this zoonotic pathogen.
The role of the patient's cSDH caused by prior trauma warrants further discussion in the pathogenesis of the infection.The vascularized membrane of the cSDH may have served as a seeding bed for the hematogenous spread of the infection and development of the subdural empyema (10), suggesting increased susceptibility in patients with cSDH or older patients with a trauma history and emphasizing the need for prompt diagnosis and treatment.
This report highlights a unique correlation to consuming a traditional dish prepared from raw pig fetuses and underscores the importance of considering dietary habits in the clinical assessment.It also raises public health concerns about the potential risks associated with consuming raw or undercooked pork products and possible S. suis endemic in Jeju Island, where extensive pig rearing and consumption take place.Increasing disease awareness among clinicians and laboratories can prevent undiagnosed or misdiagnosed cases.
E.T.K. was supported by the National Research Foundation of Korea grant, funded by the Ministry of Science and Information and Communication Technology (grant no.2021R1A2C1010313) and the Ministry of Education (grant no.RS2023-00270936), South Korea.

Figure 2 .
Figure 2. Detection of Streptococcus suis in a patient with Streptococcus suis infection, Jeju Island, South Korea, performed by using PCR with specific primers for gdh and thrA.Size marker, 1 kb DNA ladder (LugenSci, https://www.lugensci.com).Lane 1, blood culture, DNA from patient's blood culture; lane 2, subdural empyema, DNA from patient's subdural pus; lane 3, positive control, DNA from previously isolated S. suis stock; lane 4, negative control, no template PCR condition.