TY - JOUR AU - Martin, Michael AU - Weld, Leisa H. AU - Tsai, Theodore F. AU - Mootrey, Gina T. AU - Chen, Robert T. AU - Niu, Manette AU - Cetron, Martin S. T1 - Advanced Age a Risk Factor for Illness Temporally Associated with Yellow Fever Vaccination T2 - Emerging Infectious Disease journal PY - 2001 VL - 7 IS - 6 SP - 945 SN - 1080-6059 AB - In 1998, the Centers for Disease Control and Prevention was notified of severe illnesses and one death, temporally associated with yellow fever (YF) vaccination, in two elderly U.S. residents. Because the cases were unusual and adverse events following YF vaccination had not been studied, we estimated age-related reporting rates for systemic illness following YF vaccination. We found that the rate of reported adverse events among elderly vaccinees was higher than among vaccinees 25 to 44 years of age. We also found two additional deaths among elderly YF vaccinees. These data signal a potential problem but are not sufficient to reliably estimate incidence rates or to understand potential underlying mechanisms; therefore, enhanced surveillance is needed. YF remains an important cause of severe illness and death, and travel to disease-endemic regions is increasing. For elderly travelers, the risk for severe illness and death due to YF infection should be balanced against the risk for systemic illness due to YF vaccine. KW - Yellow Fever KW - vaccination KW - KW - United States DO - 10.3201/eid0706.010605 UR - https://wwwnc.cdc.gov/eid/article/7/6/01-0605_article ER - End of Reference