TY - JOUR AU - Scaletsky, Isabel C. A. AU - Fabbricotti, Sandra H. AU - Silva, Sueli O. C. AU - Morais, Mauro B. AU - Fagundes-Neto, Ulysses T1 - Hep-2–Adherent Escherichia coli Strains Associated with Acute Infantile Diarrhea, São Paulo, Brazil T2 - Emerging Infectious Disease journal PY - 2002 VL - 8 IS - 8 SP - 855 SN - 1080-6059 AB - In this paired case-control study of infants with diarrhea in São Paulo, we examined the association between HEp-2–adherent Escherichia coli strains and diarrhea. We tested isolates from stool specimens of infants with diarrhea and matched controls in an HEp-2 cell adherence assay; we then hybridized isolates with DNA probes and identified enteropathogenic E. coli (EPEC), enteroaggregative E. coli (EAEC), and diffusely adherent E. coli (DAEC). From 100 patient-control pairs, we isolated 78 HEp-2–adherent strains; of these, 61 strains were single pathogens identified in stools of infants with diarrhea. While typical EPEC was significantly associated with diarrhea (p<0.001), EAEC was more frequently associated with diarrhea in clinical cases (20%) compared with healthy controls (3%) (p<0.001). Atypical EPEC, showing a localized adherence-like pattern, was also more common in patients than controls (p>0.1). DAEC was isolated with equal frequency from patients and controls (p>0.1). KW - Adherent Escherichia coli KW - adherence KW - diarrhea KW - Brazil DO - 10.3201/eid0808.010492 UR - https://wwwnc.cdc.gov/eid/article/8/8/01-0492_article ER - End of Reference