TY - JOUR AU - Cardosa, Mary Jane AU - Perera, David AU - Brown, Betty A. AU - Cheon, Doosung AU - Chan, Hung Ming AU - Chan, Kwai Peng AU - Cho, Haewol AU - McMinn, Peter T1 - Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes T2 - Emerging Infectious Disease journal PY - 2003 VL - 9 IS - 4 SP - 462 SN - 1080-6059 AB - This study provides a comprehensive overview of the molecular epidemiology of human enterovirus 71 (HEV71) in the Asia-Pacific region from 1997 through 2002. Phylogenetic analysis of the VP4 and VP1 genes of recent HEV71 strains indicates that several genogroups of the virus have been circulating in the Asia-Pacific region since 1997. The first of these recent outbreaks, described in Sarawak (Malaysian Borneo) in 1997, was caused by genogroup B3. This outbreak was followed by large outbreaks in Taiwan in 1998, caused by genogroup C2, and in Perth (Western Australia) in 1999, where viruses belonging to genogroups B3 and C2 cocirculated. Singapore, Taiwan, and Sarawak had HEV71 epidemics in 2000, caused predominantly by viruses belonging to genogroup B4; however, large numbers of fatalities were observed only in Taiwan. HEV71 was identified during an epidemic of hand, foot and mouth disease in Korea; that epidemic was found to be due to viruses constituting a new genogroup, C3. KW - human enterovirus 71 KW - neurologic disease KW - hand KW - foot and mouth disease KW - research KW - Borneo KW - Australia KW - Singapore DO - 10.3201/eid0904.020395 UR - https://wwwnc.cdc.gov/eid/article/9/4/02-0395_article ER - End of Reference