Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 10, Number 10—October 2004
Research

Sulfa Use, Dihydropteroate Synthase Mutations, and Pneumocystis jirovecii Pneumonia

Cheryl R. Stein*, Charles Poole*, Powel Kazanjian†, and Steven R Meshnick*Comments to Author 
Author affiliations: *University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; †University of Michigan, Ann Arbor, Michigan, USA

Main Article

Table 2

Stratified and random-effects meta-regression analysis of study characteristics

Study characteristica Characteristic level No. of studies RD (95% CLD)b Homogeneity 
test p value Difference of RDs
(95% CLD)b
Prophylaxis effect on mutation
  Data collection calendar midpoint 1996 or later 6 0.22 (0.31) < 0.001 –0.32 (0.39)
Before 1996 7 0.53 (0.18) 0.8 0
4-y change 13 NA NA –0.23 (0.30)
Prophylaxis use by
  Specific mutations Yes 4 0.54 (0.24) 0.6 0.20 (0.55)
No 9 0.32 (0.29) < 0.001 0
Multiple isolates per patient Yes 5 0.50 (0.50) < 0.001 0.19 (0.52)
No 8 0.30 (0.32) < 0.001 0
Location USA 5 0.44 (0.43) < 0.001 0.10 (0.55)
Outside USA 8 0.34 (0.36) < 0.001 0
Defined treatment outcome Yes 5 0.32 (0.44) < 0.001 –0.08 (0.54)
No 8 0.41 (0.35) < 0.001 0
Multicenter Yes 5 0.41 (0.31) 0.0 0.05 (0.55)
No 8 0.36 (0.36) < 0.001 0
Proportion HIV+ 1.00 8 0.38 (0.30) < 0.001 0.03 (0.56)
< 1.00 5 0.37 (0.58) < 0.001 0

aData collection calendar midpoint, the midpoint in calendar time of data collection; defined treatment outcome, whether the study stated how it defined treatment outcome.
bRD, risk difference; CLD, confidence limit difference; NA, not applicable.

Main Article

Page created: April 11, 2011
Page updated: April 11, 2011
Page reviewed: April 11, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external