DRUG BEING STOPPED: ATOVAQUONE-PROGUANIL

CHLOROQUINE

Not recommended

DOXYCYCLINE

Begin taking doxycycline; continue taking 1×/day, at the same time each day, while in malaria-endemic areas. Take 1×/day for another 4 weeks after leaving the endemic area.

MEFLOQUINE

Not recommended

PRIMAQUINE

This switch would be unlikely because primaquine is recommended as primary prophylaxis for people with normal G6PD activity traveling to areas with mainly Plasmodium vivax. Should that be the case, begin taking primaquine. Continue taking 1×/day, at the same time each day, while in malaria-endemic areas. Take 1×/day for an additional 7 days after leaving the endemic area.

TAFENOQUINE

Not recommended

DRUG BEING STOPPED: CHLOROQUINE

ATOVAQUONE-PROGUANIL

If the switch occurs ≥3 weeks before departure from a malaria-endemic area, take atovaquone-proguanil 1×/day, at the same time each day. Continue taking 1×/day for an additional 7 days after leaving the area.

DOXYCYCLINE

Begin taking doxycycline. Continue taking 1×/day, at the same time each day, while in malaria-endemic areas. Take 1×/day for another 4 weeks after leaving the area.

MEFLOQUINE

Not recommended

PRIMAQUINE

Primaquine is recommended as primary prophylaxis for people with normal G6PD activity traveling to areas with mainly P. vivax. Should that be the case, begin taking primaquine. Continue taking 1×/day, at the same time each day, while in malaria-endemic areas. Take 1×/day for an additional 7 days after leaving the area.

TAFENOQUINE

For people with normal G6PD activity, begin taking tafenoquine as soon as possible after taking the last dose of chloroquine in a malaria-endemic area. Start by taking tafenoquine 1×/day for 3 days, then 1×/week while still in the area. Take 1 final dose during the week after leaving the endemic area.

DRUG BEING STOPPED: DOXYCYCLINE

ATOVAQUONE-PROGUANIL

If the switch occurs ≥3 weeks before departure from a malaria-endemic area, take atovaquone-proguanil 1×/day, at the same time each day. Continue taking 1×/day for an additional 7 days after leaving the endemic area.

CHLOROQUINE

Not recommended

MEFLOQUINE

Not recommended

PRIMAQUINE

This switch would be unlikely because primaquine is recommended as primary prophylaxis for people with normal G6PD activity traveling to areas with mainly P. vivax. Should that be the case, begin taking primaquine. Continue taking 1×/day, at the same time each day, while in malaria-endemic areas. Take 1×/day for an additional 7 days after leaving the endemic area.

TAFENOQUINE

Not recommended

DRUG BEING STOPPED: MEFLOQUINE

ATOVAQUONE-PROGUANIL

If the switch occurs ≥3 weeks before departure from a malaria-endemic area, take atovaquone-proguanil 1×/day, at the same time each day. Continue taking 1×/day for an additional 7 days after leaving the endemic area.

CHLOROQUINE

Not recommended

DOXYCYCLINE

Begin taking doxycycline. Continue taking 1×/day, at the same time each day, while in malaria-endemic areas. Take 1×/day for another 4 weeks after leaving the endemic area.

PRIMAQUINE

This switch would be unlikely because primaquine is recommended as primary prophylaxis for people with normal G6PD activity traveling to areas with mainly P. vivax. Should that be the case, begin taking primaquine. Continue taking 1×/day, at the same time each day, while in malaria-endemic areas. Take 1×/day for an additional 7 days after leaving the endemic area.

TAFENOQUINE

For people with normal G6PD activity, begin taking tafenoquine as soon as possible after taking the last dose of mefloquine in a malaria-endemic area. Start by taking tafenoquine 1×/day for 3 days, then 1×/week while still in the endemic area. Take 1 final dose during the week after leaving the endemic area.

DRUG BEING STOPPED: PRIMAQUINE

ATOVAQUONE-PROGUANIL

Begin taking atovaquone-proguanil. Continue taking 1×/day, at the same time each day, while in malaria-endemic areas. Take 1×/day for an additional 7 days after leaving the endemic area.

CHLOROQUINE

Not recommended

DOXYCYCLINE

Begin taking doxycycline. Continue taking 1×/day, at the same time each day, while in malaria-endemic areas. Take 1×/day for another 4 weeks after leaving the endemic area.

MEFLOQUINE

Not recommended

TAFENOQUINE

Not recommended

DRUG BEING STOPPED: TAFENOQUINE

ATOVAQUONE-PROGUANIL

Begin taking atovaquone-proguanil. Continue taking 1x/day, at the same time each day, while in malaria-endemic areas. Take 1x/day for an additional 7 days after leaving the endemic area.

CHLOROQUINE

Not recommended

DOXYCYCLINE

Begin taking doxycycline. Continue taking 1×/day, at the same time each day, while in malaria-endemic areas. Take 1×/day for another 4 weeks after leaving the endemic area.

MEFLOQUINE

Not recommended

PRIMAQUINE

Not recommended