Volume 10, Number 1—January 2004
Research
Severe Acute Respiratory Syndrome–associated Coronavirus in Lung Tissue
Tony Mazzulli*†‡, Gabriella A. Farcas‡§, Susan M. Poutanen*†‡, Barbara M. Willey*†, Donald E. Low*†‡, Jagdish Butany†‡¶, Sylvia L. Asa†‡¶, and Kevin C. Kain‡§1
Table 1
Clinical description and SARS-CoV RT-PCR results for 11 patients who died with probable SARSa
| Sex/age | Coexisting conditions | Illness and treatment duration (days) | Postmortem lung tissue description | RealArt HPA Coronavirus RT-PCRb | ||||
|---|---|---|---|---|---|---|---|---|
| Illness | Ventilation | Ribavirin | Steroids | Results | Copies of CoV/ gram tissue | |||
| M/43 | Type II DM, HTN | 15 | 4 | 0 | 0 | RUL | Positive | 1.5 x 108 |
| RML (#1) | Positive | 5.4 x 107 | ||||||
| RML (#2) | Positive | 2.8 x 107 | ||||||
| RML (#3) | Positive | 7.4 x 106 | ||||||
| RML (#4) | Positive | 6.4 x 108 | ||||||
| M/76 | Type II DM, CAD, HTN | 11 | 4 | 6 (started on day 6 of illness) | 0 | Lung | Positive | 3.8 x 109 |
| F/78 | Type II DM, CAD, hypercholesterolemia, chronic obstructive pulmonary disease | 8 | 5 | >5 (started on day 4 of illness) | 0 | RT lung | Positive | 1.0 x 109 |
| LUL | Positive | 9.4 x 107 | ||||||
| M/62 | Rectal cancer; HTN, hypercholesterolemia | 8 | N/A | >5 (started on day 4 of illness) | 0 | LT lung | Positive | 5.3 x 107 |
| F/73 | HTN, hypercholesterolemia | 28 | DNI | 14 (started on day 5 of illness) | 12 (stated on day 14 of illness) | LT lung | Positive | 3.0x 104 |
| RT lung | Positive | 3.6 x105 | ||||||
| F/99 | Osteoarthritis | 26 | DNI | 13 (started on day 1 of illness) | 0 | Lung | Positive | 5.0 x 104 |
| M/63 | Hypercholesterolemia, cerebral vascular disease | 20 | 12 | 16 (started on day 4 of illness) | 16(started on day 6 of illness) | RUL lung | Positive | 3.2 x 106 |
| LLL | Positive | 2.5 x107 | ||||||
| F/78 | Type II DM, HTN, hypercholesterolemia | 24 | 18 | 10 (started on day 3 of illness) | 18 (started on day 5 of illness) | LT lung | Positive | 4.1 x 105 |
| RUL | Positive | 4.9x105 | ||||||
| M/44 | 29 | 18 | 18 (started on day 8 of illness) | 17 (started on day 12 of illness) | RT lung | Positive | 7.6 x 104 | |
| LT lung | Positive | 4.1 x 104 | ||||||
| M/77 | Type II DM, HTN, hypercholesterolemia | >18 | >1 | >1 (started on day 10 of illness) | >7 (started on day 10 of illness) | LLL | Positive | 5.6 x 105 |
| LUL | Positive | 5.7 x 105 | ||||||
| F/79 | Type II DM, HTN, hypercholesterolemia | 32 | DNI | 11 (started on day 2 of illness) | >4 (started on day 12 of illness) | LT lung | Positive | 2.7 x 104 |
| Lung | Positive | 2.1 x 105 | ||||||
aSARS, severe acute respiratory syndrome; CoV, coronavirus; RT-PCR, reverse transcription polymerase chain reaction; F, female; M, male; DM, diabetes mellitus; HTN, hypertension; RUL, right upper lobe; RML, right middle lobe; CAD, coronary artery disease; RT, right; LT, left; LUL, left upper lobe; LLL, left lower lobe; N/A, not available; DNI, “Do not intubate” order written.
bRealArt HPA Coronavirus RT-PCR (Artus GmbH, Hamburg, Germany).
