Volume 10, Number 11—November 2004
Dispatch
Decreased Levofloxacin Susceptibility in Haemophilus influenzae in Children, Hong Kong
Pak Leung Ho*
, Kin Hung Chow*, Gannon C. Mak*, Kenneth W. Tsang*, Yu Lung Lau*, Pak-Leung Ho* , Eileen L. Lai*, and Susan S. Chiu*
, Kin Hung Chow*, Gannon C. Mak*, Kenneth W. Tsang*, Yu Lung Lau*, Pak-Leung Ho* , Eileen L. Lai*, and Susan S. Chiu*Table 2
MIC and QRDR amino acid substitutions of Haemophilus influenzae ATCC 49247 and eight clinical isolates from young children
| Isolate | School | Sex/Age (y) | MIC |
Predicated QRDR amino acid changes |
||||
|---|---|---|---|---|---|---|---|---|
| NA | LVX | AMP | AZI | GyrA | ParC | |||
| ATCC 49247 | – | – | 1 | 0.015 | 4 | 1 | 80PHGDSAVYDTIVR92 | 80PHGDSACYEAMVL92 |
| G813 | G8 | M/6 | 4 | 0.03 | 1 | 2 | None | None |
| G92 | G9 | M/4 | 4 | 0.06 | 0.25 | 1 | None | None |
| D19 | D1 | M/6 | 8 | 0.06 | 0.25 | 1 | None | None |
| L38 | L3 | F/5 | 64 | 0.125 | 0.5 | 1 | D88N (gat to aat) | None |
| J517 | J5 | M/6 | 64 | 0.125 | 0.5 | 2 | S84L (tcc to ttg) | None |
| M65 | M6 | F/6 | 64 | 0.125 | 128 | 1 | S84L (ttc to tta) | None |
| B211 | B2 | F/4 | 64 | 0.125 | 0.25 | 1 | S84L (tcc to tta) | None |
| R33 |
R3 |
F/5 |
128 |
0.125 |
0.25 |
1 |
S84L (ttc to tta) |
None |
| aQRDR, quinolone resistance-determining region; NA, nalidixic acid; LVX, levofloxacin; AMP, ampicillin; AZI, azithromycin. | ||||||||
