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Volume 10, Number 11—November 2004

Dispatch

Decreased Levofloxacin Susceptibility in Haemophilus influenzae in Children, Hong Kong

Pak Leung Ho*Comments to Author , Kin Hung Chow*, Gannon C. Mak*, Kenneth W. Tsang*, Yu Lung Lau*, Pak-Leung Ho*Comments to Author , Eileen L. Lai*, and Susan S. Chiu*
Author affiliations: *University of Hong Kong, Hong Kong Special Administrative Region, China

Main Article

Table 2

MIC and QRDR amino acid substitutions of Haemophilus influenzae ATCC 49247 and eight clinical isolates from young children

Isolate School Sex/Age (y) MIC
Predicated QRDR amino acid changes
NA LVX AMP AZI GyrA ParC
ATCC 49247 1 0.015 4 1 80PHGDSAVYDTIVR92 80PHGDSACYEAMVL92
G813 G8 M/6 4 0.03 1 2 None None
G92 G9 M/4 4 0.06 0.25 1 None None
D19 D1 M/6 8 0.06 0.25 1 None None
L38 L3 F/5 64 0.125 0.5 1 D88N (gat to aat) None
J517 J5 M/6 64 0.125 0.5 2 S84L (tcc to ttg) None
M65 M6 F/6 64 0.125 128 1 S84L (ttc to tta) None
B211 B2 F/4 64 0.125 0.25 1 S84L (tcc to tta) None
R33
R3
F/5
128
0.125
0.25
1
S84L (ttc to tta)
None
aQRDR, quinolone resistance-determining region; NA, nalidixic acid; LVX, levofloxacin; AMP, ampicillin; AZI, azithromycin.

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