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Volume 10, Number 3—March 2004

Research

Monkeypox Transmission and Pathogenesis in Prairie Dogs

Jeannette Guarner*Comments to Author , Bill J. Johnson†, Christopher D. Paddock*, Wun-Ju Shieh*, Cynthia S. Goldsmith*, Mary G. Reynolds*, Inger K. Damon*, Russell L. Regnery*, Sherif R. Zaki*, and the Veterinary Monkeypox Virus Working Group
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Oklahoma Animal Disease Diagnostic Laboratory, Oklahoma State University, Stillwater, Oklahoma, USA

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Figure 2

Ulcer on tongue of a prairie dog infected with monkeypox virus (A: hematoxylin and eosin stain, 12.5X original magnification). Orthopox viral antigens are abundant in the squamous epithelium, with lesser amounts in the ulcer bed (B: immunohistochemical stain using the anti-smallpox antibody, 12.5X original magnification). Tongue epithelial cell adjacent to epidermal basement membrane (small arrows) with Guarnieri-like inclusion (large arrow) (C: transmission electron microscopy, 2,400X original

Figure 2. Ulcer on tongue of a prairie dog infected with monkeypox virus (A: hematoxylin and eosin stain, 12.5X original magnification). Orthopox viral antigens are abundant in the squamous epithelium, with lesser amounts in the ulcer bed (B: immunohistochemical stain using the anti-smallpox antibody, 12.5X original magnification). Tongue epithelial cell adjacent to epidermal basement membrane (small arrows) with Guarnieri-like inclusion (large arrow) (C: transmission electron microscopy, 2,400X original magnification). Higher magnification of the Guarnieri-like inclusion shows intracellular immature (arrowhead) and mature (arrows) orthopox virions. The mature virions consist of a dense core surrounded by several laminated zones and enclosed within an outer membrane. (D: transmission electron microscopy, 17,000X original magnification.)

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1Veterinary Monkeypox Virus Working Group Members: CDC’s Infectious Diseases Pathology Activity: Patricia Greer, Michelle M. Packard, and William Lee, and CDC’s Poxvirus Section Laboratory: Victoria Olson, Richard Kline, Yu Li, and Linda Stempora.

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