Figure. Immunohistochemical localization of Coxiella burnetii antigens in the aortic valve of a patient co-infected with HIV. Intact bacteria and fragment antigens are identified predominantly within macrophages in the fibrosed and calcified valve tissue. (Immunoalkaline phosphatase stain with naphthol phosphate fast-red substrate and hematoxylin counterstain, original magnification X100).
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