Emerging Infectious Disease ISSN: 1080-6059

Antigenic and Genetic Variability of Human Metapneumoviruses

Bernadette G. van den Hoogen*, Sander Herfst*, Leo Sprong*, Patricia A. Cane†, Eduardo Forleo-Neto‡, Rik L. de Swart*, Albert D.M.E. Osterhaus*, and Ron A.M. Fouchier*

Author affiliations: *Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands; †University of Birmingham Medical School, Birmingham, United Kingdom; ‡Vigi Virus, São Paulo, Brazil

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Figure 1

Phylogenetic trees constructed based on the (A) partial F gene (ORF position 780–1,221, n = 84) or (B) the complete G coding region (start G ORF to start L ORF, n = 35). Trees were generated by maximum likelihood analysis using 100 bootstraps and 3 jumbles. The scale representing the percentage of nucleotide changes is shown for each tree. Bootstrap values are based on the consensus trees, and relevant numbers are shown in the tree. The four prototype viruses are shown in boldface, with ovals dr

Figure 1. Phylogenetic trees constructed based on the (A) partial F gene (ORF position 780–1,221, n = 84) or (B) the complete G coding region (start G ORF to start L ORF, n = 35). Trees were generated by maximum likelihood analysis using 100 bootstraps and 3 jumbles. The scale representing the percentage of nucleotide changes is shown for each tree. Bootstrap values are based on the consensus trees, and relevant numbers are shown in the tree. The four prototype viruses are shown in boldface, with ovals drawn around them. NL, viruses from the Netherlands; FN, viruses obtained from Finland; UK, viruses obtained from the United Kingdom; HK, viruses obtained from Hong Kong; BR, viruses obtained from Brazil.

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