Emerging Infectious Disease ISSN: 1080-6059

Antigenic and Genetic Variability of Human Metapneumoviruses

Bernadette G. van den Hoogen*, Sander Herfst*, Leo Sprong*, Patricia A. Cane†, Eduardo Forleo-Neto‡, Rik L. de Swart*, Albert D.M.E. Osterhaus*, and Ron A.M. Fouchier*

Author affiliations: *Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands; †University of Birmingham Medical School, Birmingham, United Kingdom; ‡Vigi Virus, São Paulo, Brazil

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Figure 2

Amino acid sequence comparison of the fusion protein genes of prototype human metapneumovirus isolates of each sublineage. The predicted signal peptide, fusion domain, and membrane anchor are shown in italics in boldface type, the cleavage sites are boxed, and the region sequenced for 84 samples is underlined in boldface type. Periods indicate the position of identical amino acid residues relative to isolate NL/1/00.

Figure 2. Amino acid sequence comparison of the fusion protein genes of prototype human metapneumovirus isolates of each sublineage. The predicted signal peptide, fusion domain, and membrane anchor are shown in italics in boldface type, the cleavage sites are boxed, and the region sequenced for 84 samples is underlined in boldface type. Periods indicate the position of identical amino acid residues relative to isolate NL/1/00.

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