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Volume 10, Number 4—April 2004

Research

Antigenic and Genetic Variability of Human Metapneumoviruses

Bernadette G. van den Hoogen*, Sander Herfst*, Leo Sprong*, Patricia A. Cane†, Eduardo Forleo-Neto‡, Rik L. de Swart*, Albert D.M.E. Osterhaus*, and Ron A.M. Fouchier*Comments to Author 
Author affiliations: *Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands; †University of Birmingham Medical School, Birmingham, United Kingdom; ‡Vigi Virus, São Paulo, Brazil

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Table 3

Homologous and heterologous virus neutralizing antibody titers of sera obtained from ferrets infected with HMPV viruses belonging to different genetic sublineagesa,b

Virus used in virus neutralization Ferret 3 NL/1/00 [A1] Ferret 4 NL/17/00 [A2] Ferret 5 NL/1/99 [B1] Ferret 6 UK/5/01 [B2]
NL/ 1/00
256
256
6
32
NL/17/00
512
768
12
24
NL/ 1/99
16
32
256
384
UK/ 5/01
12
64
256
512
Ratio A–B
Ratio B–A 16–21 12–24 21–43 16–21

aVirus neutralizing antibody titers obtained for sera collected 21 days post infection from ferrets 3 to 6 (infected with NL/1/00, NL/17/00, NL/1/99 and UK/5/01, respectively). HMPV, human metapneumovirus.
bHomologous virus neutralization titers are bold. Values are average of duplicate measurements. Ratios are given as the homologous virus neutralization titers divided by the heterologous virus neutralization titers.

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