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Volume 10, Number 4—April 2004

Letter

Mycobacterium tuberculosis Complex Drug Resistance in Italy

Giovanni B. Migliori*, Rosella Centis*, Lanfranco Fattorini*, Giorgio Besozzi*, Cesare Saltini*, Claudio Scarparo*, Daniela Cirillo*, A. Gori*, Antonio Cassone*, and Claudio Piersimoni*Comments to Author 
Author affiliations: *SMIRA (Italian Multicentre Study on Resistance to Antituberculosis drugs) Coordinating Committee

Main Article

Table

Pattern of drug resistance among strains from tuberculosis patients with and without a history of treatment, Italy 1998–2001a

Tested MTB strains No history of previous treatment
History of previous treatment
No. % 95% CI No. % 95% CI
Total tested
2,117
100

322
100

Fully sensitive
1,847
87.2
85.8 to 88.6
155
48.1
42.7 to 53.6
Any drug
270
12.7
11.4 to 14.2
167
51.8
46.4 to 57.3
INH
75
3.5
2.8 to 4.4
17
5.3
3.2 to 8.2
RMP
17
0.8
0.5 to 1.3
14
4.3
2.5 to 7.0
EMB
10
0.5
0.2 to 0.8
1
0.3
0.02 to 1.5
SM
93
4.3
3.6 to 5.3
14
4.3
2.5 to 7.0
Resistant to both INH and RMP
8
0.40
0.8 to 0.7
24
7.5
4.9 to 10.7
Resistant to INH, RMP, EMB
2
0.10
0.01 to 0.3
19
6.0
3.7 to 8.9
Resistant to INH, RMP, SM
6
0.30
0.1 to 0.6
23
7.1
4.7 to 10.4
Resistant to INH, RMP, EMB, SM 7 0.30 0.1 to 0.6 32 9.9 7.0 to 13.5

aMTB, Mycobacterium tuberculosis complex; CI, confidence interval; INH, isoniazid; RMP, rifampicin; EMB, ethambutol; SM, streptomycin.

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