Emerging Infectious Disease ISSN: 1080-6059

Fatal Spotted Fever Rickettsiosis, Kenya

Jeremiah S. Rutherford*, Kevin Macaluso†

, Nathaniel Smith‡, Sherif R. Zaki§, Christopher D. Paddock§, Jon Davis*, Norman Peterso*, Abdu F. Azad†, and Ronald Rosenberg*

Author affiliations: *United States Army Medical Research Unit, Nairobi, Kenya; †University of Maryland School of Medicine, Baltimore, Maryland, USA; ‡Kijabe African Inland Church Mission Hospital, Kijabe, Kenya; §Centers for Disease Control and Prevention, Atlanta, Georgia, USA

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Figure 2

Immunohistochemical localization of spotted fever group rickettsial antigens in various tissues of a patient with fatal spotted fever rickettsiosis, by immunoalkaline phosphatase stain with naphthol phosphate–fast red substrate and hemotoxylin counterstain. Rickettsiae and rickettsial antigens (red) in Kupffer cells in liver (A), perivascular infiltrates in skin (B), and glomerular endothelium in kidney (C) (naphthol–fast red stain with hematoxylin counterstain; original magnifications x158).

Figure 2. Immunohistochemical localization of spotted fever group rickettsial antigens in various tissues of a patient with fatal spotted fever rickettsiosis, by immunoalkaline phosphatase stain with naphthol phosphate–fast red substrate and hemotoxylin counterstain. Rickettsiae and rickettsial antigens (red) in Kupffer cells in liver (A), perivascular infiltrates in skin (B), and glomerular endothelium in kidney (C) (naphthol–fast red stain with hematoxylin counterstain; original magnifications x158).

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