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Volume 10, Number 5—May 2004

Research

Vancomycin Susceptibility within Methicillin-resistant Staphylococcus aureus Lineages

Robin A. Howe*, Alastair Monk†, Mandy Wootton*, Timothy R. Walsh‡, and Mark C. Enright†Comments to Author 
Author affiliations: *Southmead Hospital, Bristol, United Kingdom; †University of Bath, Bath, United Kingdom; ‡University of Bristol, Bristol, United Kingdom

Main Article

Table

Characteristics of study isolates with reduced vancomycin susceptibilitya

Genotype
Clonal type agr type Vancomycin resistance phenotype
(no. of strains) PAP-AUC Country of origin Antimicrobial susceptibility*†
CC ST SCCmec Lzd Syn Gen Cip Rif
5
5
I
EMRSA-3
II
hVISA (1)
0.98
UK
S
S
R
R
R
I
VISA (1)
1.9
USA
S
S
R
R
S
5
5
II
New York/Japanese
II
hVISA (10)
0.97–1.23
Japan, Sweden, France, Poland, UK, USA, Norway
S
S
S/R
S/R
S/R
I or II
VISA (3)
1.4–1.92
USA
S
S
S
R
S/R
5
5
IV
Pediatric
I or II
hVISA (3)
1.19–1.32
UK
S
S
S
S/R
S/R
5
5
NT

I
VISA (1)
1.44
France
S
S
R
R
R
8
8
I

II
hVISA (3)
0.92–1.32
France, UK, Norway
S
S
R
R
R
8
8
II
Irish-1
II
hVISA (3)
1.04–1.2
France, USA, Norway
S
S
S/R
R
S/R
8
8
IV
EMRSA-4, -6
I
hVISA(11)
0.94–1.24
France, USA
S
S/R
S/R
R
S/R
22
22
IV
EMRSA-15
I or II
hVISA (7)
0.9–1.25
UK
S
S
S
R
S/R
25
25
NT

I
hVISA(1)
1.13
UK
S
S
R
R
R
30
36
II
EMRSA-16
II
hVISA (3)
0.92–1.17
UK
S
S
R
R
R
45
45
II

I
hVISA (1)
1
USA
S
S
R
R
S
8
239
I or II
Brazilian/Portuguese
I or II
hVISA (10)
0.9–1.22
France, Poland, China, Norway, UK
S
S
R
S/R
S/R
I
VISA (3)
1.44–3.01
France, Poland, UK
S
S/R
R
R
S/R
8
239
NT

I
hVISA (1)
0.92
France
S
S
R
R
R
8
246
NT

I
hVISA (1)
1.13
Norway
S
S
R
R
R
8 247 I Iberian I
VISA (1)
1.57
UK
S
S
R
R
R
I or II hVISA (37) 0.9–1.33 France, Poland, UK, Norway S S R R S/R

aS, susceptible; R, resistant; NT, nontypeable; PAP-AUC, population analysis profiling followed by measuring the area under the curve; Lzd, linezolid; Syn, synercid; Gen, gentamicin; Cip, ciprofloxacin; Rif, rifampin; CC, clonal complex; ST, sequence type; EMRSA, methicillin-resistant Staphylococcus aureas found in the United Kingdom (UK) ; hVISA, heterogeneous vancomycin-intermediate S. aureus; USA, United States of America.

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