Volume 10, Number 6—June 2004
Research
Respiratory Picornaviruses and Respiratory Syncytial Virus as Causative Agents of Acute Expiratory Wheezing in Children
Tuomas Jartti*
, Pasi Lehtinen*, Tytti Vuorinen†, Riikka Österback†, Bernadette van den Hoogen‡, Albert D.M.E. Osterhaus‡, and Olli Ruuskanen*
, Pasi Lehtinen*, Tytti Vuorinen†, Riikka Österback†, Bernadette van den Hoogen‡, Albert D.M.E. Osterhaus‡, and Olli Ruuskanen*Table 2
Viral etiology of acute expiratory wheezing in childrena
| Y of study (Ref.) | Wheezing episodes | Age (y) | Methods for virus detection |
Viral identification rates (%) |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Culture | Antigen | Serology | PCR | RSV | Rhino | Entero | PIV types 1–3 | Influ. A/B | Adeno | Corona | HMPV | Total pos. | ||||
| 1965 (17) |
225 |
0–16 |
+ |
8 |
3 |
5 |
4 |
0 |
4 |
27 |
||||||
| 1971 (18) |
855 |
0–14 |
+ |
9 |
2 |
1 |
8 |
1 |
2 |
25 |
||||||
| 1975 (19) |
1,515 |
0–12 |
+ |
3 |
12 |
3 |
3 |
2 |
1 |
23 |
||||||
| 1976 (20) |
267 |
1–12 |
+ |
+ |
4 |
6 |
1 |
1 |
1 |
3 |
14 |
|||||
| 1979 (21) |
1,851 |
0–15 |
+ |
7 |
1 |
6 |
2 |
21 |
||||||||
| 1979 (22) |
554 |
0–12 |
+ |
2 |
13 |
4 |
4 |
2 |
1 |
26 |
||||||
| 1979 (23) |
72 |
5–15 |
+ |
1 |
28 |
3 |
10 |
1 |
49 |
|||||||
| 1984 (24) |
256 |
2–15 |
+ |
+ |
+ |
5 |
4 |
2 |
3 |
2 |
29 |
|||||
| 1987 (25) |
204 |
0–12 |
+ |
+ |
+ |
6 |
1 |
5 |
0 |
3 |
2 |
19 |
||||
| 1993 (26) |
99 |
0.2–16 |
+ |
+ |
14 |
19 |
3 |
0 |
2 |
0 |
36 |
|||||
| 1996 (27) |
181 |
0.3–2 |
+ |
+ |
12 |
6 |
1 |
7 |
2 |
26 |
||||||
| 1999 (3) |
70 |
0.2–16 |
+ |
+ |
+ |
26 |
61 |
1 |
1 |
4 |
83 |
|||||
| 1999 (28) |
132 |
0.3–14 |
+ |
+ |
21 |
47 |
10 |
4 |
5 |
5 |
5 |
82 |
||||
| 2000 (29) |
84 |
0.7 |
+ |
+ |
54 |
10 |
8 |
0 |
0 |
13 |
0 |
74 |
||||
| 2002 (30) |
118 |
0–1.5 |
+ |
53 |
21 |
3 |
3 |
8 |
3 |
74 |
||||||
| 2003 (4) | 179 | 0.1–17 | + | + | + | 7 | 79 | 1 | 2 | 2 | 88 | |||||
aSampling period of at least 12 mo.
bRSV, respiratory syncytial virus; PCR, polymerase chain reaction; rhino, rhinovirus; entero, enterovirus, PIV, parainfluenza virus; influ., influenza virus; adeno, adenovirus; corona, coronavirus; HMPV, human metapnemovirus; pos., positive.
