Global Genetic Diversity of Human Metapneumovirus Fusion Gene
Guy Boivin* , Ian M. Mackay†, Theo P. Sloots†, Shabir Madhi‡, François Freymuth§, Dana Wolf¶, Yonat Shemer-Avni#, Herbert Ludewick‡, Gregory C. Gray**, and Éric Leblanc*
Author affiliations: *Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada; †Royal Children’s Hospital, Herston, Queensland, Australia; ‡University of Witwatersrand, Bertsham, South Africa; §Centre Hospitalier Universitaire de Caen, Caen, France; ¶Hadassah University Hospital, Jerusalem, Israel; #Soroka Medical Center, Beer Sheva, Israel; **University of Iowa, Iowa City, Iowa, USA
Figure 2. Amino acid sequence alignment of the fusion (F) protein of various human metapneumovirus (HMPV) strains and other paramyxoviruses. Amino acid numbering is based on the sequence of the HMPV strain NETH-001 (GenBank accession no. AF371337). Amino acids shown are those different than NETH-001. Boxed residues represent conserved cysteines. Potential N-glycosylation sites are underlined. The fusion domain is indicated by italics in the consensus sequence, whereas the heptad repeat A region is indicated by bold characters. Shaded residues represent significant substitutions between HMPV groups and subgroups. Note that only distinct HMPV strains were included in the alignment. PVM, pneumonia virus of mice; BRSV, bovine respiratory syncytial virus; HRSV, human respiratory syncytial virus; APV, avian pneumovirus; RSA, Republic of South Africa; CAN, Canada; FRA, France; AUS, Australia; NETH, the Netherlands.
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