Emerging Infectious Disease ISSN: 1080-6059

Mice Susceptible to SARS Coronavirus

David E. Wentworth*

, Laura Gillim-Ross*, Noel Espina*, and Kristen A. Bernard*†

Author affiliations: *New York Department of Health, Albany, New York, USA; †State University of New York, Albany, New York, USA

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Figure 2

Mice inoculated with severe acute respiratory syndrome–associated coronavirus showed decreased weight gain and developed neutralizing antibodies. A. Average percentage original weight for 2 to 5 mock-inoculated (gray line and solid squares) and 6 to 15 virus-inoculated (solid line and open circles) mice. Error bars represent 1 standard deviation. B. Neutralization titers reported as reciprocal of serum dilution for individual mock-inoculated (solid bars) and virus-inoculated (hashed bars) mice a

Figure 2. Mice inoculated with severe acute respiratory syndrome–associated coronavirus showed decreased weight gain and developed neutralizing antibodies. A. Average percentage original weight for 2 to 5 mock-inoculated (gray line and solid squares) and 6 to 15 virus-inoculated (solid line and open circles) mice. Error bars represent 1 standard deviation. B. Neutralization titers reported as reciprocal of serum dilution for individual mock-inoculated (solid bars) and virus-inoculated (hashed bars) mice at time of sacrifice. Lowest dilution tested was 1:20.

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