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Volume 10, Number 8—August 2004

Research

Thrombocytopenia and Acute Renal Failure in Puumala Hantavirus Infections

Franz Maximilian Rasche*Comments to Author , Boris Uhel*, Rainer Ulrich†, Detlev H. Krüger†, Wolfram Karges*, David Czock*, Walter Hampl*, Frieder Keller*, Helga Meisel†, and Lutz von Müller*
Author affiliations: *University Hospital Ulm, Ulm, Germany; †Charité, Berlin, Germany

Main Article

Table 2

Virologic results of 15 patients with acute PUUV infection

Patient IgG-EIA (Progen) index IgG titers IgM titers c-FRNT titers

PUUV
PUUV
HTNV
DOBV
PUUV
PUUV
HTNV
DOBV
SEOV
TULV
1
9
6,400
Neg
Neg
3,200
640
<40
160
<40
160
2
2.1
2,560
640

2,560





3
2.2
6,400
400
400
1,600
2,560
<40
<40
<40
40
4
3.3
51,200
6,400
400
12,800
640
160
40
<40
160
5
3.8
51,200
3,200
Neg
bPos
2,560
160
40
<40
40
6
3.1
6,400
800
Neg
6,400
2,560
640
40
<40
160
7
3.1
12,800
800
Neg
1,280
640
<40
<40

40
8
4.3
12,800
3,200
800
3,200
2,560
160
40
<40
160
9
1.8
cPos


cPos





10
2.9
12,800
3,200
3,200
400
2,560
160
40
<40
160
11
7.1
12,800
1,600
400
1,600





12
2.9
cPos


cPos





13
4.9
51,200
400
Neg
3,200





14
2.5
cPos


cPos





15 3.3 12,800 1,600 400 1,600 2,560 40 <40 40 40

aPUUV, Puumala virus; Ig, immunoglobulin; EIA, enzyme immunoassay; c-FRNT, chemiluminescence focus reduction neutralization assays; HTNV, Hantaan virus; DOBV, Dobrava virus; SEOV, Seoul virus; TULV, Tula virus; –, not available.
bIgM-EIA (Progen, Heidelberg, Germany).
cImmunoblot (Mikrogene, Martinsried, Germany).

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