Volume 10, Number 8—August 2004
Research
Thrombocytopenia and Acute Renal Failure in Puumala Hantavirus Infections
Franz Maximilian Rasche*
, Boris Uhel*, Rainer Ulrich†, Detlev H. Krüger†, Wolfram Karges*, David Czock*, Walter Hampl*, Frieder Keller*, Helga Meisel†, and Lutz von Müller*
, Boris Uhel*, Rainer Ulrich†, Detlev H. Krüger†, Wolfram Karges*, David Czock*, Walter Hampl*, Frieder Keller*, Helga Meisel†, and Lutz von Müller*Table 2
Virologic results of 15 patients with acute PUUV infection
| Patient | IgG-EIA (Progen) index | IgG titers | IgM titers | c-FRNT titers | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PUUV |
PUUV |
HTNV |
DOBV |
PUUV |
PUUV |
HTNV |
DOBV |
SEOV |
TULV |
|
| 1 |
9 |
6,400 |
Neg |
Neg |
3,200 |
640 |
<40 |
160 |
<40 |
160 |
| 2 |
2.1 |
2,560 |
640 |
– |
2,560 |
– |
– |
– |
– |
– |
| 3 |
2.2 |
6,400 |
400 |
400 |
1,600 |
2,560 |
<40 |
<40 |
<40 |
40 |
| 4 |
3.3 |
51,200 |
6,400 |
400 |
12,800 |
640 |
160 |
40 |
<40 |
160 |
| 5 |
3.8 |
51,200 |
3,200 |
Neg |
bPos |
2,560 |
160 |
40 |
<40 |
40 |
| 6 |
3.1 |
6,400 |
800 |
Neg |
6,400 |
2,560 |
640 |
40 |
<40 |
160 |
| 7 |
3.1 |
12,800 |
800 |
Neg |
1,280 |
640 |
<40 |
<40 |
– |
40 |
| 8 |
4.3 |
12,800 |
3,200 |
800 |
3,200 |
2,560 |
160 |
40 |
<40 |
160 |
| 9 |
1.8 |
cPos |
– |
– |
cPos |
– |
– |
– |
– |
– |
| 10 |
2.9 |
12,800 |
3,200 |
3,200 |
400 |
2,560 |
160 |
40 |
<40 |
160 |
| 11 |
7.1 |
12,800 |
1,600 |
400 |
1,600 |
– |
– |
– |
– |
– |
| 12 |
2.9 |
cPos |
– |
– |
cPos |
– |
– |
– |
– |
– |
| 13 |
4.9 |
51,200 |
400 |
Neg |
3,200 |
– |
– |
– |
– |
|
| 14 |
2.5 |
cPos |
– |
– |
cPos |
– |
– |
– |
– |
– |
| 15 | 3.3 | 12,800 | 1,600 | 400 | 1,600 | 2,560 | 40 | <40 | 40 | 40 |
aPUUV, Puumala virus; Ig, immunoglobulin; EIA, enzyme immunoassay; c-FRNT, chemiluminescence focus reduction neutralization assays; HTNV, Hantaan virus; DOBV, Dobrava virus; SEOV, Seoul virus; TULV, Tula virus; –, not available.
bIgM-EIA (Progen, Heidelberg, Germany).
cImmunoblot (Mikrogene, Martinsried, Germany).
