Emerging Infectious Disease ISSN: 1080-6059

Experimental Infection of Ground Squirrels (Spermophilus tridecemlineatus) with Monkeypox Virus

Robert B. Tesh*

, Douglas M. Watts*, Elena Sbrana*, Marina Siirin*, Vsevolod L. Popov*, and Shu-Yuan Xiao*

Author affiliations: *University of Texas Medical Branch, Galveston, Texas, USA

Figure 2

Ultrastructural localization of monkeypox virus in hepatocytes in the liver of a ground squirrel 5 days after infection. A) Hepatocytes contain numerous groups of virions (arrows) in their cytoplasm (bar = 1 μm). B) Magnified area of A, showing typical ultrastructure of monkeypox virus virions and characteristic hepatocyte mitochondria (M) surrounded by cisterns of granular endoplasmic reticulum (er). N, fragment of hepatocyte nucleus; bar = 0.5 μm.

Figure 2. Ultrastructural localization of monkeypox virus in hepatocytes in the liver of a ground squirrel 5 days after infection. A) Hepatocytes contain numerous groups of virions (arrows) in their cytoplasm (bar = 1 μm). B) Magnified area of A, showing typical ultrastructure of monkeypox virus virions and characteristic hepatocyte mitochondria (M) surrounded by cisterns of granular endoplasmic reticulum (er). N, fragment of hepatocyte nucleus; bar = 0.5 μm.

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