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Volume 11, Number 11—November 2005

Research

Neutralizing Antibody Response and SARS Severity

Mei-Shang Ho*, Wei-Ju Chen*, Hour-Young Chen†, Szu-Fong Lin†, Min-Chin Wang†, Jiali Di†, Yen-Ta Lu‡, Ching-Lung Liu‡, Shan-Chwen Chang§, Chung-Liang Chao¶, Chwan-Chuen King§, Jeng-Min Chiou*, Ih-Jen Su#, and Jyh-Yuan Yang†Comments to Author 
Author affiliations: *Academia Sinica, Taipei, Taiwan; †Center for Disease Control, Taipei, Taiwan; ‡Taipei Mackay Memorial Hospital, Taipei, Taiwan; §National Taiwan University, Taipei, Taiwan; ¶Taipei Hospital, Taipei, Taiwan; #National Health Research Institutes, Taipei, Taiwan

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Table 6

Comparison of early seroresponders and other SARS patients, by death rate, time of death, and age*

Factor Early seroresponders†
OR p value‡
Yes, n (%) No, n (%)
Died
Yes 29.6 (8) 7.8 (10) 4.97 0.004
No 70.4 (19) 92.2 (118) 1.00
Died within 2 wk
Yes 75.0 (6) 10.0 (1) 0.013
No 25.0 (2) 90.0 (9)
Age (y)
>60 (n = 14) 42.9 (6) 57.1 (8) 0.01
<60 (n = 141) 14.9 (21) 85.1 (120)

*SARS, severe acute respiratory syndrome; OR, odds ratio.
†Early seroresponders are SARS patients who were seropositive for SARS neutralizing antibody during the first 2 weeks of illness.
‡p value based on Fisher exact test.

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