Volume 11, Number 4—April 2005
Research
Childhood Hemolytic Uremic Syndrome, United Kingdom and Ireland
Richard M. Lynn*, Sarah J. O’Brien†1
, C. Mark Taylor‡, Goutam K. Adak†, Henrik Chart§, Tom Cheasty§, John E. Coia¶, Iain A. Gillespie†, Mary E. Locking#, William J. Reilly#, Henry R. Smith§, Aoife Waters**, and Geraldine A. Willshaw§
, C. Mark Taylor‡, Goutam K. Adak†, Henrik Chart§, Tom Cheasty§, John E. Coia¶, Iain A. Gillespie†, Mary E. Locking#, William J. Reilly#, Henry R. Smith§, Aoife Waters**, and Geraldine A. Willshaw§Table 2
Clinical features and acute complications of diarrhea-associated hemolytic uremic syndrome (HUS) in children from the 1997–2001 British Paediatric Surveillance Unit survey compared with children from the 1985–1988 survey
| 1985–1988 survey | 1997–2001 survey | p value | |
|---|---|---|---|
| No. of cases | 288 | 413 | |
| Cases with a diarrheal prodrome | 273 (95%) | 395 (96%) | 0.6 |
| Mean (range) time from onset of diarrhea to diagnosis of HUS | 8 days (1–34) | 6 days (range 1–35) | <0.001 |
| Severe acute abdominal symptoms | 40 (15%) | 36 (9%) | 0.03 |
| Seizures or other neurologic complications | 51(19%) | 52 (13%) | 0.06 |
| Hypertension | 86 (32%) | 92 (23%) | 0.02 |
| Cardiomyopathy | 4 (1%) | 7 (2%) | 1.0 |
| Diabetes mellitus | 4 (1%) | 8 (2%) | 0.77 |
