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Volume 11, Number 4—April 2005

Letter

Route of Infection in Melioidosis

Jodie L. Barnes*Comments to Author  and Natkunam Ketheesan*
Author affiliations: *James Cook University, Townsville, Queensland, Australia

Main Article

Table

Ten-day LD50* values (given in CFU) after intravenous, intraperitoneal, subcutaneous, intranasal, or oral introduction of NCTC 13178 or NCTC 13179 
strains of Burholderia pseudomallei into BALB/c or C57BL/6 mice

Route of infection NCTC 13178
NCTC 13179
BALB/c C57BL/6 BALB/c C57BL/6
Intravenous <10 5 x 103 9 x 103 6 x 106
Intraperitoneal 1.2 x 101 9.7 x 103 4.7 x 105 2.1 x 107
Subcutaneous 1 x 103 9 x 105 9 x 102 >108
Intranasal† 1.4 x 102 1.8 x 103 1.9 x 106 >108
Oral‡ 7.2 x 103 1.8 106 4.8 x 106 >108


*50% lethal dose.
†20 μL of challenge dose was introduced intranasally onto the nostrils of the mice by using a pipette tip.
‡20 μL of challenge dose was introduced orally to the back of the throat of the mice by using a pipette tip.

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