Volume 11, Number 4—April 2005
Dispatch
Molecular Mechanisms of West Nile Virus Pathogenesis in Brain Cells
Wee-Lee Koh* and Mah-Lee Ng*
Table 1
Differentially regulated genes involved in pathogenesis of A172 cells infected with West Nile virus
| Gene | Gene name | Fold change |
|---|---|---|
| Immune response related | ||
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100 kDa | 2.32 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 3.46 |
| FIT1 | Interferon-induced protein with tetratricopeptide repeats 1 | 10.74 |
| IFIT2 | Interferon-induced protein with tetratricopeptide repeats 2 | 3.76 |
| IFI27 | Interferon, α-inducible protein 27 | 4.03 |
| IFITM1 | Interferon-induced transmembrane protein 1 (9-27) | 12.00 |
| IFITM2 | Interferon-induced transmembrane protein 2 (1-8D) | 3.04 |
| G1P2 | Interferon, α-inducible protein (clone IFI-15K) | 9.50 |
| HLA-C | Major histocompatibility complex, class I, C | 2.20 |
| INDO | Indoleamine-pyrrole 2,3 dioxygenase | 3.38 |
| PTX3 | Pentaxin-related gene, rapidly induced by interleukin-1β | 3.44 |
| Apoptosis related | ||
| TNFSF14 | Tumor necrosis factor (TNF) (ligand) superfamily, member 14 | 2.19 |
| NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer | 4.13 |
| TRAF1 | TNF receptor-associated factor 1 | 2.01 |
| SAT | Spermidine/spermine N1-acetyltransferase | 2.18 |
| Mitochondria related | ||
| SDHC | Succinate dehydrogenase complex, subunit C | –2.31 |
| COX5B | Cytochrome c oxidase subunit Vb | –2.13 |
| COX6B | Cytochrome c oxidase subunit VIb | –2.41 |
| ATP5G1 | ATP synthase, mitochondrial F0 complex, subunit c, isoform 1 | –2.64 |
| ATP5C1 | ATP synthase, mitochondrial F1 complex, γ polypeptide 1 | –3.82 |
| ATP5J | ATP synthase, mitochondrial F0 complex, subunit F6 | –2.11 |
| ATP5B | ATP synthase, mitochondrial F1 complex, β polypeptide | –2.17 |
| ATP5A1 | ATP synthase, mitochondrial F1 complex, α subunit, isoform 1 | –2.21 |
| ATP5O | ATP synthase, mitochondrial F1 complex, O subunit | –2.00 |
| ATP5F1 | ATP synthase, mitochondrial F0 complex, subunit b, isoform 1 | –2.43 |
| PRDX5 | Peroxiredoxin 5 | –2.74 |
| PRDX3 | Peroxiredoxin 3 | –2.27 |
| Protein biosynthesis related | ||
| NACA | Nascent-polypeptide-associated complex polypeptide | –2.17 |
