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Volume 11, Number 4—April 2005

Dispatch

Molecular Mechanisms of West Nile Virus Pathogenesis in Brain Cells

Wee-Lee Koh* and Mah-Lee Ng*Comments to Author 
Author affiliations: *National University of Singapore, Singapore

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Table 1

Differentially regulated genes involved in pathogenesis of A172 cells infected with West Nile virus

Gene Gene name Fold change
Immune response related
OAS3 2'-5'-oligoadenylate synthetase 3, 100 kDa 2.32
OASL 2'-5'-oligoadenylate synthetase-like 3.46
FIT1 Interferon-induced protein with tetratricopeptide repeats 1 10.74
IFIT2 Interferon-induced protein with tetratricopeptide repeats 2 3.76
IFI27 Interferon, α-inducible protein 27 4.03
IFITM1 Interferon-induced transmembrane protein 1 (9-27) 12.00
IFITM2 Interferon-induced transmembrane protein 2 (1-8D) 3.04
G1P2 Interferon, α-inducible protein (clone IFI-15K) 9.50
HLA-C Major histocompatibility complex, class I, C 2.20
INDO Indoleamine-pyrrole 2,3 dioxygenase 3.38
PTX3 Pentaxin-related gene, rapidly induced by interleukin-1β 3.44
Apoptosis related
TNFSF14 Tumor necrosis factor (TNF) (ligand) superfamily, member 14 2.19
NFKBIA Nuclear factor of kappa light polypeptide gene enhancer 4.13
TRAF1 TNF receptor-associated factor 1 2.01
SAT Spermidine/spermine N1-acetyltransferase 2.18
Mitochondria related
SDHC Succinate dehydrogenase complex, subunit C –2.31
COX5B Cytochrome c oxidase subunit Vb –2.13
COX6B Cytochrome c oxidase subunit VIb –2.41
ATP5G1 ATP synthase, mitochondrial F0 complex, subunit c, isoform 1 –2.64
ATP5C1 ATP synthase, mitochondrial F1 complex, γ polypeptide 1 –3.82
ATP5J ATP synthase, mitochondrial F0 complex, subunit F6 –2.11
ATP5B ATP synthase, mitochondrial F1 complex, β polypeptide –2.17
ATP5A1 ATP synthase, mitochondrial F1 complex, α subunit, isoform 1 –2.21
ATP5O ATP synthase, mitochondrial F1 complex, O subunit –2.00
ATP5F1 ATP synthase, mitochondrial F0 complex, subunit b, isoform 1 –2.43
PRDX5 Peroxiredoxin 5 –2.74
PRDX3 Peroxiredoxin 3 –2.27
Protein biosynthesis related
NACA Nascent-polypeptide-associated complex polypeptide –2.17

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