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Volume 11, Number 4—April 2005

Dispatch

Molecular Mechanisms of West Nile Virus Pathogenesis in Brain Cells

Wee-Lee Koh* and Mah-Lee Ng*Comments to Author 
Author affiliations: *National University of Singapore, Singapore

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Table 2

Comparison of gene expression changes between microarray and qRT-PCR in A172 cells infected with West Nile virus*

Gene Gene name Microarray fold change RT-PCR fold change
ARHI DIRAS family, GTP-binding RAS-like 3 –2.72 –2.55
ATP5J ATP synthase, mitochondrial F0 complex, subunit F6 –2.11 –2.60
CEB1 Hect domain and RLD 5 2.32 42.22
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 –1.97 –2.14
DUSP1 Dual specificity phosphatase 1 1.92 5.66
EGR1 Early growth response 1 4.79 8.57
EIF4G2 Eukaryotic translation initiation factor 4 γ, 2 –2.11 –7.77
FLJ13855 Hypothetical protein FLJ13855 2.05 3.85
FOSL1 FOS-like antigen 1 2.08 6.50
IFITM1 Interferon-induced transmembrane protein 1 (9-27) 12.03 527.61
LTA4H Leukotriene A4 hydrolase –2.02 –8.10
RPL5 Ribosomal protein L5 –2.97 –9.03
RPL7A Ribosomal protein L7a –2.03 –3.42
RPLP0 Ribosomal protein, large, P0 –2.15 –1.52
TFPI2 Tissue factor pathway inhibitor 2 5.21 11.58

*qRT-PCR, quantitative reverse transcription–polymerase chain reaction.

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